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Mutation:
MSH6 L773P
Summary
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Hereditary cancer-predisposing syndrome, Lynch syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 767T
Affected site:
Position: 767
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 767A | ERVDTCH[T/A]TPFGKRLL | 0 |
direct
|
| 767N | ERVDTCH[T/N]TPFGKRLL | 0 |
direct
|
| 767S | ERVDTCH[T/S]TPFGKRLL | 0 |
direct
|
| 767I | ERVDTCH[T/I]TPFGKRLL | 0 |
direct
|
| 766Y | ERVDTC[H/Y]HTPFGKRLL | 1 |
proximal
|
PTM Site: 771K
Affected site:
Position: 771
Residue: K
Type: ubiquitination
Impact:
proximalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 771T | TCHTPFG[K/T]KRLLKQWL | 0 |
direct
|
| 771M | TCHTPFG[K/M]KRLLKQWL | 0 |
direct
|
| 771N | TCHTPFG[K/N]KRLLKQWL | 0 |
direct
|
| 770D | TCHTPF[G/D]GKRLLKQWL | 1 |
proximal
|
| 772G | TCHTPFGK[R/G]RLLKQWL | 1 |
proximal
|
External references
dbSNP:
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