After several years of serving the research community, our ActiveDriverDB database will be retired on May 1st 2026. Please make sure to download any data you need and update your links or workflows before that date.
We want to sincerely thank all our users for their support, feedback, and collaboration over the years — your contributions have been invaluable to this project. A special thank you to Dr. Michal Krassowski for leading the development of our open-source software and database.
For any questions or assistance, please contact Jüri Reimand (juri.reimand@utoronto.ca).
You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:
PDE4B S140R
Summary
Isoform:
Position:
140
Ref:
S
Mutation:
R
PTM impact:
direct
PTM affected:
5
Kinases:
PKA group,
PRKACA
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
[0.0077]
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 133S
Affected site:
Position: 133
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|
PTM Site: 138S
Affected site:
Position: 138
Residue: S
Type: phosphorylation
Only gain of PTM site:
PRKCA (probability p=0.861)
Site: 138S (phosphorylation)
Position in motif: 2
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 140R | RESFLYRSD[S/R]SDYDLS | 2 |
network-rewiring
|
| 141V | RESFLYRSDS[D/V]DYDLS | 3 |
network-rewiring
|
| 141Y | RESFLYRSDS[D/Y]DYDLS | 3 |
network-rewiring
|
PTM Site: 140S
Affected site:
Position: 140
Residue: S
Type: phosphorylation
Impact:
directOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 140R | SFLYRSD[S/R]SDYDLSPK | 0 |
direct
|
| 141V | SFLYRSDS[D/V]DYDLSPK | 1 |
proximal
|
| 141Y | SFLYRSDS[D/Y]DYDLSPK | 1 |
proximal
|
| 146S | SFLYRSDSDYDLS[P/S]PK | 6 |
distal
|
PTM Site: 142Y
Affected site:
Position: 142
Residue: Y
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 140R | LYRSD[S/R]SDYDLSPKAM | 2 |
proximal
|
| 141V | LYRSDS[D/V]DYDLSPKAM | 1 |
proximal
|
| 141Y | LYRSDS[D/Y]DYDLSPKAM | 1 |
proximal
|
| 146S | LYRSDSDYDLS[P/S]PKAM | 4 |
distal
|
PTM Site: 145S
Affected site:
Position: 145
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 140R | SD[S/R]SDYDLSPKAMSRN | 5 |
distal
|
| 150L | SDSDYDLSPKAM[S/L]SRN | 5 |
distal
|
| 141V | SDS[D/V]DYDLSPKAMSRN | 4 |
distal
|
| 141Y | SDS[D/Y]DYDLSPKAMSRN | 4 |
distal
|
| 146S | SDSDYDLS[P/S]PKAMSRN | 1 |
network-rewiring
|
If you have any questions or feedback about this mutation:
Contact us