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Mutation:
PDE4B D141V
Summary
Isoform:
Position:
141
Ref:
D
Mutation:
V
PTM impact:
network-rewiring
PTM affected:
4
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
LUAD
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 138S
Affected site:
Position: 138
Residue: S
Type: phosphorylation
Only loss of PTM site:
CSNK2A1 (probability p=0.902)
Site: 138S (phosphorylation)
Position in motif: 3
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 140R | RESFLYRSD[S/R]SDYDLS | 2 |
network-rewiring
|
| 141V | RESFLYRSDS[D/V]DYDLS | 3 |
network-rewiring
|
| 141Y | RESFLYRSDS[D/Y]DYDLS | 3 |
network-rewiring
|
PTM Site: 140S
Affected site:
Position: 140
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 140R | SFLYRSD[S/R]SDYDLSPK | 0 |
direct
|
| 141V | SFLYRSDS[D/V]DYDLSPK | 1 |
proximal
|
| 141Y | SFLYRSDS[D/Y]DYDLSPK | 1 |
proximal
|
| 146S | SFLYRSDSDYDLS[P/S]PK | 6 |
distal
|
PTM Site: 142Y
Affected site:
Position: 142
Residue: Y
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 140R | LYRSD[S/R]SDYDLSPKAM | 2 |
proximal
|
| 141V | LYRSDS[D/V]DYDLSPKAM | 1 |
proximal
|
| 141Y | LYRSDS[D/Y]DYDLSPKAM | 1 |
proximal
|
| 146S | LYRSDSDYDLS[P/S]PKAM | 4 |
distal
|
PTM Site: 145S
Affected site:
Position: 145
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 140R | SD[S/R]SDYDLSPKAMSRN | 5 |
distal
|
| 150L | SDSDYDLSPKAM[S/L]SRN | 5 |
distal
|
| 141V | SDS[D/V]DYDLSPKAMSRN | 4 |
distal
|
| 141Y | SDS[D/Y]DYDLSPKAMSRN | 4 |
distal
|
| 146S | SDSDYDLS[P/S]PKAMSRN | 1 |
network-rewiring
|
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