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Mutation:
TP53 S46Y
Summary
Isoform:
Position:
46
Ref:
S
Mutation:
Y
PTM impact:
direct
PTM affected:
1
Kinases:
ATM,
DYRK2,
PRKCD,
MAPK14,
PRKDC,
HIPK2,
CDK5,
MAPK9
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Li-Fraumeni syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 46S
Affected site:
Position: 46
Residue: S
Type: phosphorylation
Impact:
directOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 52R | AMDDLMLSPDDIE[Q/R]QW | 6 |
distal
|
| 51G | AMDDLMLSPDDI[E/G]EQW | 5 |
distal
|
| 51K | AMDDLMLSPDDI[E/K]EQW | 5 |
distal
|
| 50T | AMDDLMLSPDD[I/T]IEQW | 4 |
distal
|
| 50N | AMDDLMLSPDD[I/N]IEQW | 4 |
distal
|
| 49G | AMDDLMLSPD[D/G]DIEQW | 3 |
network-rewiring
|
| 49H | AMDDLMLSPD[D/H]DIEQW | 3 |
network-rewiring
|
| 49N | AMDDLMLSPD[D/N]DIEQW | 3 |
network-rewiring
|
| 48E | AMDDLMLSP[D/E]DDIEQW | 2 |
proximal
|
| 47R | AMDDLMLS[P/R]PDDIEQW | 1 |
network-rewiring
|
| 47S | AMDDLMLS[P/S]PDDIEQW | 1 |
network-rewiring
|
| 47T | AMDDLMLS[P/T]PDDIEQW | 1 |
network-rewiring
|
| 46Y | AMDDLML[S/Y]SPDDIEQW | 0 |
direct
|
| 46P | AMDDLML[S/P]SPDDIEQW | 0 |
direct
|
| 45P | AMDDLM[L/P]LSPDDIEQW | 1 |
proximal
|
| 45V | AMDDLM[L/V]LSPDDIEQW | 1 |
proximal
|
| 44I | AMDDL[M/I]MLSPDDIEQW | 2 |
proximal
|
| 44R | AMDDL[M/R]MLSPDDIEQW | 2 |
network-rewiring
|
| 43F | AMDD[L/F]LMLSPDDIEQW | 3 |
distal
|
| 43M | AMDD[L/M]LMLSPDDIEQW | 3 |
distal
|
| 42G | AMD[D/G]DLMLSPDDIEQW | 4 |
distal
|
| 41G | AM[D/G]DDLMLSPDDIEQW | 5 |
distal
|
| 41N | AM[D/N]DDLMLSPDDIEQW | 5 |
distal
|
| 48N | AMDDLMLSP[D/N]DDIEQW | 2 |
proximal
|
External references
dbSNP:
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