[{"gene":"ERCC5","protein":"NM_000123","pos":19,"alt":"L","ref":"P","cnt_ptm":0,"ptm_impact":"none","summary":[0.0615],"value":0.0615,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0615,"MAF EA":0.093,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":145,"alt":"I","ref":"V","cnt_ptm":0,"ptm_impact":"none","summary":[0.6997],"value":0.6997,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.6997,"MAF EA":0.0,"MAF AA":2.0654}}},{"gene":"ERCC5","protein":"NM_000123","pos":181,"alt":"R","ref":"H","cnt_ptm":0,"ptm_impact":"none","summary":[0.0308],"value":0.0308,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0308,"MAF EA":0.0349,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":214,"alt":"C","ref":"R","cnt_ptm":1,"ptm_impact":"distal","summary":[0.0308],"value":0.0308,"closest_sites":["209 K"],"sites":[{"position":209,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0308,"MAF EA":0.0116,"MAF AA":0.0681}}},{"gene":"ERCC5","protein":"NM_000123","pos":214,"alt":"H","ref":"R","cnt_ptm":1,"ptm_impact":"distal","summary":[0.2768],"value":0.2768,"closest_sites":["209 K"],"sites":[{"position":209,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.2768,"MAF EA":0.0,"MAF AA":0.8171}}},{"gene":"ERCC5","protein":"NM_000123","pos":254,"alt":"V","ref":"M","cnt_ptm":1,"ptm_impact":"proximal","summary":[2.6757],"value":2.6757,"closest_sites":["252 K"],"sites":[{"position":252,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":2.6757,"MAF EA":3.593,"MAF AA":0.8852}}},{"gene":"ERCC5","protein":"NM_000123","pos":256,"alt":"R","ref":"Q","cnt_ptm":1,"ptm_impact":"distal","summary":[2.5988],"value":2.5988,"closest_sites":["252 K"],"sites":[{"position":252,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":2.5988,"MAF EA":0.2093,"MAF AA":7.2628}}},{"gene":"ERCC5","protein":"NM_000123","pos":263,"alt":"Q","ref":"R","cnt_ptm":0,"ptm_impact":"none","summary":[0.0384],"value":0.0384,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0384,"MAF EA":0.0581,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":311,"alt":"C","ref":"S","cnt_ptm":3,"ptm_impact":"network-rewiring","summary":[0.0384],"value":0.0384,"closest_sites":["313 K"],"sites":[{"position":307,"type":"phosphorylation","residue":"S","pmid":[],"kinases":[],"kinase_groups":[]},{"position":313,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]},{"position":318,"type":"phosphorylation","residue":"S","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0384,"MAF EA":0.0,"MAF AA":0.1135},"MIMP":{"gain":[],"loss":[{"effect":"loss","pwm":"GSK3A","kinase":{"refseq":"NM_019884"},"pos_in_motif":4,"pwm_family":"GSK","site":{"position":307,"type":"phosphorylation","residue":"S","pmid":[]},"probability":0.902152}],"effect":"loss"}}},{"gene":"ERCC5","protein":"NM_000123","pos":344,"alt":"A","ref":"T","cnt_ptm":2,"ptm_impact":"distal","summary":[0.0384],"value":0.0384,"closest_sites":["341 S"],"sites":[{"position":338,"type":"phosphorylation","residue":"T","pmid":[18669648,20068231,15302935],"kinases":[],"kinase_groups":[]},{"position":341,"type":"phosphorylation","residue":"S","pmid":[18669648,20166139,20068231,15302935],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0384,"MAF EA":0.0581,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":420,"alt":"H","ref":"R","cnt_ptm":2,"ptm_impact":"network-rewiring","summary":[0.0846],"value":0.0846,"closest_sites":["423 S"],"sites":[{"position":423,"type":"phosphorylation","residue":"S","pmid":[18669648],"kinases":[],"kinase_groups":[]},{"position":424,"type":"phosphorylation","residue":"S","pmid":[18669648],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0846,"MAF EA":0.0,"MAF AA":0.2497},"MIMP":{"gain":[],"loss":[{"effect":"loss","pwm":"PAK1","kinase":{"refseq":"NM_002576"},"pos_in_motif":-3,"pwm_family":"STE20_PAKA","site":{"position":423,"type":"phosphorylation","residue":"S","pmid":[18669648]},"probability":0.957965},{"effect":"loss","pwm":"AKT1","kinase":{"refseq":"NM_005163"},"pos_in_motif":-3,"pwm_family":"Akt","site":{"position":423,"type":"phosphorylation","residue":"S","pmid":[18669648]},"probability":0.950879},{"effect":"loss","pwm":"PRKAA1","kinase":{"refseq":"NM_006251"},"pos_in_motif":-3,"pwm_family":"CAMKL_AMPK","site":{"position":423,"type":"phosphorylation","residue":"S","pmid":[18669648]},"probability":0.865571}],"effect":"loss"}}},{"gene":"ERCC5","protein":"NM_000123","pos":500,"alt":"W","ref":"R","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":529,"alt":"S","ref":"C","cnt_ptm":2,"ptm_impact":"network-rewiring","summary":[4.3211],"value":4.3211,"closest_sites":["526 S"],"sites":[{"position":523,"type":"phosphorylation","residue":"T","pmid":[],"kinases":[],"kinase_groups":[]},{"position":526,"type":"phosphorylation","residue":"S","pmid":[18220336,17322306,18767875,19664995,19664994,20068231,15302935],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":4.3211,"MAF EA":4.314,"MAF AA":4.335},"MIMP":{"gain":[{"effect":"gain","pwm":"CSNK1E","kinase":{"refseq":"NM_001894"},"pos_in_motif":3,"pwm_family":"CK1_CK1-D","site":{"position":526,"type":"phosphorylation","residue":"S","pmid":[18220336,17322306,18767875,19664995,19664994,20068231,15302935]},"probability":0.901454}],"loss":[],"effect":"gain"}}},{"gene":"ERCC5","protein":"NM_000123","pos":590,"alt":"I","ref":"V","cnt_ptm":0,"ptm_impact":"none","summary":[0.0615],"value":0.0615,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0615,"MAF EA":0.0581,"MAF AA":0.0681}}},{"gene":"ERCC5","protein":"NM_000123","pos":597,"alt":"L","ref":"V","cnt_ptm":0,"ptm_impact":"none","summary":[0.246],"value":0.246,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.246,"MAF EA":0.3372,"MAF AA":0.0681}}},{"gene":"ERCC5","protein":"NM_000123","pos":627,"alt":"E","ref":"A","cnt_ptm":0,"ptm_impact":"none","summary":[0.0769],"value":0.0769,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0769,"MAF EA":0.0814,"MAF AA":0.0681}}},{"gene":"ERCC5","protein":"NM_000123","pos":761,"alt":"T","ref":"A","cnt_ptm":0,"ptm_impact":"none","summary":[0.0846],"value":0.0846,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0846,"MAF EA":0.1279,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":874,"alt":"T","ref":"A","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":879,"alt":"S","ref":"N","cnt_ptm":0,"ptm_impact":"none","summary":[0.9611],"value":0.9611,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.9611,"MAF EA":1.3953,"MAF AA":0.1135}}},{"gene":"ERCC5","protein":"NM_000123","pos":940,"alt":"M","ref":"V","cnt_ptm":0,"ptm_impact":"none","summary":[0.123],"value":0.123,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.123,"MAF EA":0.1395,"MAF AA":0.0908}}},{"gene":"ERCC5","protein":"NM_000123","pos":1036,"alt":"T","ref":"A","cnt_ptm":1,"ptm_impact":"distal","summary":[0.0692],"value":0.0692,"closest_sites":["1032 S"],"sites":[{"position":1032,"type":"phosphorylation","residue":"S","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0692,"MAF EA":0.0814,"MAF AA":0.0454}}},{"gene":"ERCC5","protein":"NM_000123","pos":1053,"alt":"R","ref":"G","cnt_ptm":1,"ptm_impact":"distal","summary":[0.2537],"value":0.2537,"closest_sites":["1050 K"],"sites":[{"position":1050,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.2537,"MAF EA":0.0,"MAF AA":0.749}}},{"gene":"ERCC5","protein":"NM_000123","pos":1080,"alt":"E","ref":"G","cnt_ptm":0,"ptm_impact":"none","summary":[0.2076],"value":0.2076,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.2076,"MAF EA":0.0233,"MAF AA":0.5674}}},{"gene":"ERCC5","protein":"NM_000123","pos":1104,"alt":"H","ref":"D","cnt_ptm":0,"ptm_impact":"none","summary":[30.5782],"value":30.5782,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":30.5782,"MAF EA":22.8837,"MAF AA":45.5969}}},{"gene":"ERCC5","protein":"NM_000123","pos":1119,"alt":"V","ref":"A","cnt_ptm":0,"ptm_impact":"none","summary":[0.1153],"value":0.1153,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.1153,"MAF EA":0.1163,"MAF AA":0.1135}}},{"gene":"ERCC5","protein":"NM_000123","pos":1143,"alt":"T","ref":"A","cnt_ptm":0,"ptm_impact":"none","summary":[0.1076],"value":0.1076,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.1076,"MAF EA":0.0,"MAF AA":0.3177}}},{"gene":"ERCC5","protein":"NM_000123","pos":34,"alt":"C","ref":"W","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":45,"alt":"H","ref":"R","cnt_ptm":0,"ptm_impact":"none","summary":[0.0384],"value":0.0384,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0384,"MAF EA":0.0,"MAF AA":0.1135}}},{"gene":"ERCC5","protein":"NM_000123","pos":52,"alt":"D","ref":"N","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":98,"alt":"E","ref":"A","cnt_ptm":1,"ptm_impact":"network-rewiring","summary":[0.0077],"value":0.0077,"closest_sites":["100 S"],"sites":[{"position":100,"type":"phosphorylation","residue":"S","pmid":[20068231],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0},"MIMP":{"gain":[{"effect":"gain","pwm":"PLK1","kinase":{"refseq":"NM_005030"},"pos_in_motif":-2,"pwm_family":"PLK","site":{"position":100,"type":"phosphorylation","residue":"S","pmid":[20068231]},"probability":0.962839}],"loss":[],"effect":"gain"}}},{"gene":"ERCC5","protein":"NM_000123","pos":101,"alt":"E","ref":"D","cnt_ptm":1,"ptm_impact":"proximal","summary":[0.0077],"value":0.0077,"closest_sites":["100 S"],"sites":[{"position":100,"type":"phosphorylation","residue":"S","pmid":[20068231],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":106,"alt":"A","ref":"T","cnt_ptm":2,"ptm_impact":"distal","summary":[0.0077],"value":0.0077,"closest_sites":["111 K"],"sites":[{"position":100,"type":"phosphorylation","residue":"S","pmid":[20068231],"kinases":[],"kinase_groups":[]},{"position":111,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":131,"alt":"P","ref":"L","cnt_ptm":1,"ptm_impact":"distal","summary":[0.0077],"value":0.0077,"closest_sites":["126 K"],"sites":[{"position":126,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":185,"alt":"V","ref":"A","cnt_ptm":0,"ptm_impact":"none","summary":[0.0154],"value":0.0154,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0154,"MAF EA":0.0233,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":198,"alt":"A","ref":"P","cnt_ptm":0,"ptm_impact":"none","summary":[0.0231],"value":0.0231,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0231,"MAF EA":0.0349,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":222,"alt":"I","ref":"M","cnt_ptm":0,"ptm_impact":"none","summary":[0.0231],"value":0.0231,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0231,"MAF EA":0.0,"MAF AA":0.0681}}},{"gene":"ERCC5","protein":"NM_000123","pos":239,"alt":"I","ref":"K","cnt_ptm":2,"ptm_impact":"proximal","summary":[0.0077],"value":0.0077,"closest_sites":["240 K"],"sites":[{"position":235,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]},{"position":240,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":242,"alt":"C","ref":"Y","cnt_ptm":2,"ptm_impact":"proximal","summary":[0.0154],"value":0.0154,"closest_sites":["240 K"],"sites":[{"position":235,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]},{"position":240,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0154,"MAF EA":0.0,"MAF AA":0.0454}}},{"gene":"ERCC5","protein":"NM_000123","pos":258,"alt":"Y","ref":"H","cnt_ptm":1,"ptm_impact":"distal","summary":[0.0077],"value":0.0077,"closest_sites":["252 K"],"sites":[{"position":252,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":276,"alt":"I","ref":"V","cnt_ptm":1,"ptm_impact":"proximal","summary":[0.0077],"value":0.0077,"closest_sites":["274 K"],"sites":[{"position":274,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":324,"alt":"F","ref":"S","cnt_ptm":3,"ptm_impact":"proximal","summary":[0.0077],"value":0.0077,"closest_sites":["322 K"],"sites":[{"position":318,"type":"phosphorylation","residue":"S","pmid":[],"kinases":[],"kinase_groups":[]},{"position":322,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]},{"position":331,"type":"phosphorylation","residue":"T","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":342,"alt":"T","ref":"P","cnt_ptm":2,"ptm_impact":"network-rewiring","summary":[0.0077],"value":0.0077,"closest_sites":["341 S"],"sites":[{"position":338,"type":"phosphorylation","residue":"T","pmid":[18669648,20068231,15302935],"kinases":[],"kinase_groups":[]},{"position":341,"type":"phosphorylation","residue":"S","pmid":[18669648,20166139,20068231,15302935],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227},"MIMP":{"gain":[],"loss":[{"effect":"loss","pwm":"MAPK3","kinase":{"refseq":"NM_002746"},"pos_in_motif":1,"pwm_family":"MAPK_ERK1","site":{"position":341,"type":"phosphorylation","residue":"S","pmid":[18669648,20166139,20068231,15302935]},"probability":0.994177},{"effect":"loss","pwm":"MAPK12","kinase":{"refseq":"NM_002969"},"pos_in_motif":1,"pwm_family":"MAPK_p38","site":{"position":341,"type":"phosphorylation","residue":"S","pmid":[18669648,20166139,20068231,15302935]},"probability":0.96863},{"effect":"loss","pwm":"MAPK14","kinase":{"refseq":"NM_139012"},"pos_in_motif":1,"pwm_family":"MAPK_p38","site":{"position":341,"type":"phosphorylation","residue":"S","pmid":[18669648,20166139,20068231,15302935]},"probability":0.967826},{"effect":"loss","pwm":"CDK5","kinase":{"refseq":"NM_004935"},"pos_in_motif":1,"pwm_family":"CDK","site":{"position":341,"type":"phosphorylation","residue":"S","pmid":[18669648,20166139,20068231,15302935]},"probability":0.937639},{"effect":"loss","pwm":"MAPK1","kinase":{"refseq":"NM_002745"},"pos_in_motif":1,"pwm_family":"MAPK_ERK1","site":{"position":341,"type":"phosphorylation","residue":"S","pmid":[18669648,20166139,20068231,15302935]},"probability":0.937457},{"effect":"loss","pwm":"CDK2","kinase":{"refseq":"NM_001798"},"pos_in_motif":1,"pwm_family":"CDK_CDC2","site":{"position":341,"type":"phosphorylation","residue":"S","pmid":[18669648,20166139,20068231,15302935]},"probability":0.92944},{"effect":"loss","pwm":"GSK3B","kinase":{"refseq":"NM_001146156"},"pos_in_motif":1,"pwm_family":"GSK","site":{"position":341,"type":"phosphorylation","residue":"S","pmid":[18669648,20166139,20068231,15302935]},"probability":0.918694},{"effect":"loss","pwm":"CDK1","kinase":{"refseq":"NM_001786"},"pos_in_motif":1,"pwm_family":"CDK_CDC2","site":{"position":341,"type":"phosphorylation","residue":"S","pmid":[18669648,20166139,20068231,15302935]},"probability":0.914125},{"effect":"loss","pwm":"CDK4","kinase":{"refseq":"NM_000075"},"pos_in_motif":1,"pwm_family":"CDK","site":{"position":341,"type":"phosphorylation","residue":"S","pmid":[18669648,20166139,20068231,15302935]},"probability":0.913801},{"effect":"loss","pwm":"MAPK9","kinase":{"refseq":"NM_002752"},"pos_in_motif":1,"pwm_family":"MAPK_JNK","site":{"position":341,"type":"phosphorylation","residue":"S","pmid":[18669648,20166139,20068231,15302935]},"probability":0.906937},{"effect":"loss","pwm":"CDK7","kinase":{"refseq":"NM_001799"},"pos_in_motif":1,"pwm_family":"CDK","site":{"position":341,"type":"phosphorylation","residue":"S","pmid":[18669648,20166139,20068231,15302935]},"probability":0.862883}],"effect":"loss"}}},{"gene":"ERCC5","protein":"NM_000123","pos":370,"alt":"H","ref":"R","cnt_ptm":1,"ptm_impact":"distal","summary":[0.0077],"value":0.0077,"closest_sites":["363 S"],"sites":[{"position":363,"type":"phosphorylation","residue":"S","pmid":[20068231],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":376,"alt":"V","ref":"A","cnt_ptm":1,"ptm_impact":"distal","summary":[0.0615],"value":0.0615,"closest_sites":["382 S"],"sites":[{"position":382,"type":"phosphorylation","residue":"S","pmid":[18669648,20068231],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0615,"MAF EA":0.0,"MAF AA":0.1816}}},{"gene":"ERCC5","protein":"NM_000123","pos":386,"alt":"L","ref":"R","cnt_ptm":4,"ptm_impact":"network-rewiring","summary":[0.0077],"value":0.0077,"closest_sites":["384 S"],"sites":[{"position":382,"type":"phosphorylation","residue":"S","pmid":[18669648,20068231],"kinases":[],"kinase_groups":[]},{"position":384,"type":"phosphorylation,phosphorylation (SARS-CoV-2)","residue":"S","pmid":[17322306,18767875,20068231,18691976,32645325,18669648,19413330,15302935,19664994,19664995,19651622,19415658,18220336,18491316,18452278,20058876,17081983],"kinases":[],"kinase_groups":[]},{"position":389,"type":"phosphorylation","residue":"S","pmid":[],"kinases":[],"kinase_groups":[]},{"position":392,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0},"MIMP":{"gain":[],"loss":[{"effect":"loss","pwm":"AKT1","kinase":{"refseq":"NM_005163"},"pos_in_motif":-3,"pwm_family":"Akt","site":{"position":389,"type":"phosphorylation","residue":"S","pmid":[]},"probability":0.990143},{"effect":"loss","pwm":"PRKCA","kinase":{"refseq":"NM_002737"},"pos_in_motif":2,"pwm_family":"PKC_Alpha","site":{"position":384,"type":"phosphorylation,phosphorylation (SARS-CoV-2)","residue":"S","pmid":[17322306,18767875,20068231,18691976,32645325,18669648,19413330,15302935,19664994,19664995,19651622,19415658,18220336,18491316,18452278,20058876,17081983]},"probability":0.9296},{"effect":"loss","pwm":"PRKCG","kinase":{"refseq":"NM_002739"},"pos_in_motif":2,"pwm_family":"PKC_Alpha","site":{"position":384,"type":"phosphorylation,phosphorylation (SARS-CoV-2)","residue":"S","pmid":[17322306,18767875,20068231,18691976,32645325,18669648,19413330,15302935,19664994,19664995,19651622,19415658,18220336,18491316,18452278,20058876,17081983]},"probability":0.912603},{"effect":"loss","pwm":"RPS6KB1","kinase":{"refseq":"NM_003161"},"pos_in_motif":-3,"pwm_family":"RSK_p70","site":{"position":389,"type":"phosphorylation","residue":"S","pmid":[]},"probability":0.898794},{"effect":"loss","pwm":"PRKACA","kinase":{"refseq":"NM_002730"},"pos_in_motif":-3,"pwm_family":"PKA","site":{"position":389,"type":"phosphorylation","residue":"S","pmid":[]},"probability":0.896586},{"effect":"loss","pwm":"CAMK4","kinase":{"refseq":"NM_001744"},"pos_in_motif":-3,"pwm_family":"CAMK1","site":{"position":389,"type":"phosphorylation","residue":"S","pmid":[]},"probability":0.882749},{"effect":"loss","pwm":"PRKAA1","kinase":{"refseq":"NM_006251"},"pos_in_motif":-3,"pwm_family":"CAMKL_AMPK","site":{"position":389,"type":"phosphorylation","residue":"S","pmid":[]},"probability":0.866743},{"effect":"loss","pwm":"PRKCD","kinase":{"refseq":"NM_006254"},"pos_in_motif":-3,"pwm_family":"PKC_Delta","site":{"position":389,"type":"phosphorylation","residue":"S","pmid":[]},"probability":0.862187},{"effect":"loss","pwm":"CAMK2A","kinase":{"refseq":"NM_171825"},"pos_in_motif":-3,"pwm_family":"CAMK2","site":{"position":389,"type":"phosphorylation","residue":"S","pmid":[]},"probability":0.8615}],"effect":"loss"}}},{"gene":"ERCC5","protein":"NM_000123","pos":406,"alt":"R","ref":"G","cnt_ptm":1,"ptm_impact":"distal","summary":[0.0077],"value":0.0077,"closest_sites":["402 K"],"sites":[{"position":402,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":419,"alt":"I","ref":"M","cnt_ptm":2,"ptm_impact":"distal","summary":[0.0077],"value":0.0077,"closest_sites":["423 S"],"sites":[{"position":423,"type":"phosphorylation","residue":"S","pmid":[18669648],"kinases":[],"kinase_groups":[]},{"position":424,"type":"phosphorylation","residue":"S","pmid":[18669648],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":443,"alt":"S","ref":"T","cnt_ptm":0,"ptm_impact":"none","summary":[0.0692],"value":0.0692,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0692,"MAF EA":0.0,"MAF AA":0.2043}}},{"gene":"ERCC5","protein":"NM_000123","pos":458,"alt":"I","ref":"V","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":460,"alt":"T","ref":"S","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":492,"alt":"A","ref":"S","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":500,"alt":"Q","ref":"R","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":508,"alt":"F","ref":"V","cnt_ptm":0,"ptm_impact":"none","summary":[0.0154],"value":0.0154,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0154,"MAF EA":0.0233,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":557,"alt":"N","ref":"D","cnt_ptm":4,"ptm_impact":"network-rewiring","summary":[0.0077],"value":0.0077,"closest_sites":["558 S"],"sites":[{"position":558,"type":"phosphorylation","residue":"S","pmid":[18669648,17081983],"kinases":[],"kinase_groups":[]},{"position":559,"type":"phosphorylation","residue":"S","pmid":[18669648,19651622,17081983],"kinases":[],"kinase_groups":[]},{"position":562,"type":"phosphorylation","residue":"S","pmid":[17322306,18767875,19651622,20068231,18669648,19413330,18452278,17081983],"kinases":[],"kinase_groups":[]},{"position":563,"type":"phosphorylation","residue":"S","pmid":[17322306,18767875,19651622,20068231,18669648,19413330,18452278,15302935,17081983],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227},"MIMP":{"gain":[],"loss":[{"effect":"loss","pwm":"PLK1","kinase":{"refseq":"NM_005030"},"pos_in_motif":-2,"pwm_family":"PLK","site":{"position":559,"type":"phosphorylation","residue":"S","pmid":[18669648,19651622,17081983]},"probability":0.906369}],"effect":"loss"}}},{"gene":"ERCC5","protein":"NM_000123","pos":558,"alt":"T","ref":"S","cnt_ptm":4,"ptm_impact":"direct","summary":[0.0077],"value":0.0077,"closest_sites":["558 S"],"sites":[{"position":558,"type":"phosphorylation","residue":"S","pmid":[18669648,17081983],"kinases":[],"kinase_groups":[]},{"position":559,"type":"phosphorylation","residue":"S","pmid":[18669648,19651622,17081983],"kinases":[],"kinase_groups":[]},{"position":562,"type":"phosphorylation","residue":"S","pmid":[17322306,18767875,19651622,20068231,18669648,19413330,18452278,17081983],"kinases":[],"kinase_groups":[]},{"position":563,"type":"phosphorylation","residue":"S","pmid":[17322306,18767875,19651622,20068231,18669648,19413330,18452278,15302935,17081983],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":564,"alt":"G","ref":"D","cnt_ptm":5,"ptm_impact":"proximal","summary":[0.0077],"value":0.0077,"closest_sites":["563 S"],"sites":[{"position":558,"type":"phosphorylation","residue":"S","pmid":[18669648,17081983],"kinases":[],"kinase_groups":[]},{"position":559,"type":"phosphorylation","residue":"S","pmid":[18669648,19651622,17081983],"kinases":[],"kinase_groups":[]},{"position":562,"type":"phosphorylation","residue":"S","pmid":[17322306,18767875,19651622,20068231,18669648,19413330,18452278,17081983],"kinases":[],"kinase_groups":[]},{"position":563,"type":"phosphorylation","residue":"S","pmid":[17322306,18767875,19651622,20068231,18669648,19413330,18452278,15302935,17081983],"kinases":[],"kinase_groups":[]},{"position":567,"type":"phosphorylation","residue":"T","pmid":[19651622],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":565,"alt":"G","ref":"D","cnt_ptm":5,"ptm_impact":"network-rewiring","summary":[0.0077],"value":0.0077,"closest_sites":["563 S","567 T"],"sites":[{"position":558,"type":"phosphorylation","residue":"S","pmid":[18669648,17081983],"kinases":[],"kinase_groups":[]},{"position":559,"type":"phosphorylation","residue":"S","pmid":[18669648,19651622,17081983],"kinases":[],"kinase_groups":[]},{"position":562,"type":"phosphorylation","residue":"S","pmid":[17322306,18767875,19651622,20068231,18669648,19413330,18452278,17081983],"kinases":[],"kinase_groups":[]},{"position":563,"type":"phosphorylation","residue":"S","pmid":[17322306,18767875,19651622,20068231,18669648,19413330,18452278,15302935,17081983],"kinases":[],"kinase_groups":[]},{"position":567,"type":"phosphorylation","residue":"T","pmid":[19651622],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0},"MIMP":{"gain":[],"loss":[{"effect":"loss","pwm":"CAMK2A","kinase":{"refseq":"NM_171825"},"pos_in_motif":2,"pwm_family":"CAMK2","site":{"position":563,"type":"phosphorylation","residue":"S","pmid":[17322306,18767875,19651622,20068231,18669648,19413330,18452278,15302935,17081983]},"probability":0.868257},{"effect":"loss","pwm":"CSNK2A1","kinase":{"refseq":"NM_001895"},"pos_in_motif":3,"pwm_family":"CK2","site":{"position":562,"type":"phosphorylation","residue":"S","pmid":[17322306,18767875,19651622,20068231,18669648,19413330,18452278,17081983]},"probability":0.856649}],"effect":"loss"}}},{"gene":"ERCC5","protein":"NM_000123","pos":571,"alt":"S","ref":"P","cnt_ptm":1,"ptm_impact":"distal","summary":[0.0615],"value":0.0615,"closest_sites":["567 T"],"sites":[{"position":567,"type":"phosphorylation","residue":"T","pmid":[19651622],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0615,"MAF EA":0.0,"MAF AA":0.1816}}},{"gene":"ERCC5","protein":"NM_000123","pos":601,"alt":"G","ref":"E","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":604,"alt":"L","ref":"V","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":609,"alt":"I","ref":"K","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":618,"alt":"V","ref":"I","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":662,"alt":"N","ref":"S","cnt_ptm":1,"ptm_impact":"direct","summary":[0.0077],"value":0.0077,"closest_sites":["662 S"],"sites":[{"position":662,"type":"phosphorylation","residue":"S","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":680,"alt":"R","ref":"Q","cnt_ptm":1,"ptm_impact":"network-rewiring","summary":[0.0154],"value":0.0154,"closest_sites":["678 S"],"sites":[{"position":678,"type":"phosphorylation","residue":"S","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0154,"MAF EA":0.0,"MAF AA":0.0454},"MIMP":{"gain":[{"effect":"gain","pwm":"PRKCA","kinase":{"refseq":"NM_002737"},"pos_in_motif":2,"pwm_family":"PKC_Alpha","site":{"position":678,"type":"phosphorylation","residue":"S","pmid":[]},"probability":0.970957},{"effect":"gain","pwm":"PRKCE","kinase":{"refseq":"NM_005400"},"pos_in_motif":2,"pwm_family":"PKC_Eta","site":{"position":678,"type":"phosphorylation","residue":"S","pmid":[]},"probability":0.915295},{"effect":"gain","pwm":"PRKCG","kinase":{"refseq":"NM_002739"},"pos_in_motif":2,"pwm_family":"PKC_Alpha","site":{"position":678,"type":"phosphorylation","residue":"S","pmid":[]},"probability":0.887586}],"loss":[],"effect":"gain"}}},{"gene":"ERCC5","protein":"NM_000123","pos":691,"alt":"R","ref":"G","cnt_ptm":0,"ptm_impact":"none","summary":[0.0154],"value":0.0154,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0154,"MAF EA":0.0,"MAF AA":0.0454}}},{"gene":"ERCC5","protein":"NM_000123","pos":721,"alt":"V","ref":"A","cnt_ptm":1,"ptm_impact":"distal","summary":[0.0077],"value":0.0077,"closest_sites":["724 S"],"sites":[{"position":724,"type":"phosphorylation","residue":"S","pmid":[18452278,17081983],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":766,"alt":"R","ref":"G","cnt_ptm":0,"ptm_impact":"none","summary":[0.0231],"value":0.0231,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0231,"MAF EA":0.0,"MAF AA":0.0681}}},{"gene":"ERCC5","protein":"NM_000123","pos":774,"alt":"K","ref":"E","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":788,"alt":"I","ref":"M","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":822,"alt":"H","ref":"Y","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":899,"alt":"V","ref":"A","cnt_ptm":1,"ptm_impact":"distal","summary":[0.0077],"value":0.0077,"closest_sites":["904 K"],"sites":[{"position":904,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":903,"alt":"R","ref":"P","cnt_ptm":1,"ptm_impact":"proximal","summary":[0.0077],"value":0.0077,"closest_sites":["904 K"],"sites":[{"position":904,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":919,"alt":"W","ref":"R","cnt_ptm":2,"ptm_impact":"proximal","summary":[0.0077],"value":0.0077,"closest_sites":["920 T"],"sites":[{"position":920,"type":"phosphorylation","residue":"T","pmid":[20068231],"kinases":[],"kinase_groups":[]},{"position":924,"type":"phosphorylation","residue":"T","pmid":[20068231],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":923,"alt":"P","ref":"L","cnt_ptm":2,"ptm_impact":"proximal","summary":[0.0077],"value":0.0077,"closest_sites":["924 T"],"sites":[{"position":920,"type":"phosphorylation","residue":"T","pmid":[20068231],"kinases":[],"kinase_groups":[]},{"position":924,"type":"phosphorylation","residue":"T","pmid":[20068231],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":934,"alt":"K","ref":"E","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":939,"alt":"S","ref":"P","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":946,"alt":"E","ref":"G","cnt_ptm":1,"ptm_impact":"distal","summary":[0.0077],"value":0.0077,"closest_sites":["952 K"],"sites":[{"position":952,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":955,"alt":"I","ref":"L","cnt_ptm":1,"ptm_impact":"distal","summary":[0.0077],"value":0.0077,"closest_sites":["952 K"],"sites":[{"position":952,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":959,"alt":"S","ref":"R","cnt_ptm":1,"ptm_impact":"distal","summary":[0.3691],"value":0.3691,"closest_sites":["952 K"],"sites":[{"position":952,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.3691,"MAF EA":0.0,"MAF AA":1.0894}}},{"gene":"ERCC5","protein":"NM_000123","pos":964,"alt":"Q","ref":"R","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":971,"alt":"A","ref":"T","cnt_ptm":1,"ptm_impact":"proximal","summary":[0.0384],"value":0.0384,"closest_sites":["972 K"],"sites":[{"position":972,"type":"ubiquitination","residue":"K","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0384,"MAF EA":0.0581,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":992,"alt":"Q","ref":"R","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":1009,"alt":"H","ref":"R","cnt_ptm":1,"ptm_impact":"network-rewiring","summary":[0.0384],"value":0.0384,"closest_sites":["1012 S"],"sites":[{"position":1012,"type":"phosphorylation","residue":"S","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0384,"MAF EA":0.0,"MAF AA":0.1135},"MIMP":{"gain":[],"loss":[{"effect":"loss","pwm":"AKT1","kinase":{"refseq":"NM_005163"},"pos_in_motif":-3,"pwm_family":"Akt","site":{"position":1012,"type":"phosphorylation","residue":"S","pmid":[]},"probability":0.911811},{"effect":"loss","pwm":"CHEK2","kinase":{"refseq":"NM_007194"},"pos_in_motif":-3,"pwm_family":"RAD53","site":{"position":1012,"type":"phosphorylation","residue":"S","pmid":[]},"probability":0.880726},{"effect":"loss","pwm":"PRKAA1","kinase":{"refseq":"NM_006251"},"pos_in_motif":-3,"pwm_family":"CAMKL_AMPK","site":{"position":1012,"type":"phosphorylation","residue":"S","pmid":[]},"probability":0.868168},{"effect":"loss","pwm":"DAPK3","kinase":{"refseq":"NM_001348"},"pos_in_motif":-3,"pwm_family":"DAPK_DAPK","site":{"position":1012,"type":"phosphorylation","residue":"S","pmid":[]},"probability":0.861704}],"effect":"loss"}}},{"gene":"ERCC5","protein":"NM_000123","pos":1030,"alt":"T","ref":"A","cnt_ptm":1,"ptm_impact":"proximal","summary":[0.0154],"value":0.0154,"closest_sites":["1032 S"],"sites":[{"position":1032,"type":"phosphorylation","residue":"S","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0154,"MAF EA":0.0,"MAF AA":0.0454}}},{"gene":"ERCC5","protein":"NM_000123","pos":1080,"alt":"R","ref":"G","cnt_ptm":0,"ptm_impact":"none","summary":[0.2537],"value":0.2537,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.2537,"MAF EA":0.0,"MAF AA":0.749}}},{"gene":"ERCC5","protein":"NM_000123","pos":1097,"alt":"A","ref":"S","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":1129,"alt":"L","ref":"S","cnt_ptm":2,"ptm_impact":"direct","summary":[0.0077],"value":0.0077,"closest_sites":["1129 S"],"sites":[{"position":1129,"type":"phosphorylation","residue":"S","pmid":[],"kinases":[],"kinase_groups":[]},{"position":1132,"type":"phosphorylation","residue":"S","pmid":[],"kinases":[],"kinase_groups":[]}],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":1142,"alt":"R","ref":"G","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":1143,"alt":"E","ref":"A","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0116,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":1148,"alt":"C","ref":"S","cnt_ptm":0,"ptm_impact":"none","summary":[0.0154],"value":0.0154,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0154,"MAF EA":0.0233,"MAF AA":0.0}}},{"gene":"ERCC5","protein":"NM_000123","pos":1150,"alt":"G","ref":"D","cnt_ptm":0,"ptm_impact":"none","summary":[0.0077],"value":0.0077,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0077,"MAF EA":0.0,"MAF AA":0.0227}}},{"gene":"ERCC5","protein":"NM_000123","pos":1185,"alt":"T","ref":"K","cnt_ptm":0,"ptm_impact":"none","summary":[0.0544],"value":0.0544,"closest_sites":[],"sites":[],"in_datasets":{"ESP6500":{"MAF":0.0544,"MAF EA":0.0821,"MAF AA":0.0}}}]