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MAPT (NM_016835) - microtubule associated protein tau
Microtubule-Associated Protein Tau Isoform 1
Exact position of a PTM site
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This is preferred isoform of MAPT protein. View all 8 isoforms
MAPT: microtubule-associated protein tau isoform 1
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008].
- 758 residues
- All mutations
- PTM sites
- 44,039,703 - 44,101,537
- 43,971,747 - 44,105,699
98.42% of sequence is predicted to be disordered
Mappings retrieved from NCBI & Uniprot.
- gene: 4137