The results shown here are in whole or part based upon data generated by the TCGA Research Network:
(as requested on

This portal uses PhosphositePlus data which is not for commercial use; please see Terms and Conditions on following page: Terms of Use and License.

Publications of databases providing essential data for ActiveDriverDB:

  • Dinkel, H. et al. Phospho.ELM: a database of phosphorylation sites--update 2011. Nucleic acids research 39, D261-267, doi:10.1093/nar/gkq1104 (2011).
  • Keshava Prasad, T. S. et al. Human Protein Reference Database--2009 update. Nucleic acids research 37, D767-772, doi:10.1093/nar/gkn892 (2009).
  • Cancer Genome Atlas Research, N. et al. The Cancer Genome Atlas Pan-Cancer analysis project. Nature genetics 45, 1113-1120, doi:10.1038/ng.2764 (2013).
  • Genomes Project, C. et al. A global reference for human genetic variation. Nature 526, 68-74, doi:10.1038/nature15393 (2015).
  • Tennessen, J. A. et al. Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science 337, 64-69, doi:10.1126/science.1219240 (2012).
  • Landrum, M. J. et al. ClinVar: public archive of relationships among sequence variation and human phenotype. Nucleic Acids Res 42, D980-985, doi:10.1093/nar/gkt1113 (2014).

We used following resources to provide external references (protein mappings):

Pathways lists are based on a gmt file retrieved from g:Profiler resource:

  • J. Reimand, T. Arak, P. Adler, L. Kolberg, S. Reisberg, H. Peterson, J. Vilo: g:Profiler -- a web server for functional interpretation of gene lists (2016 update) Nucleic Acids Research 2016; doi: 10.1093/nar/gkw199

Protein description summaries and full protein names (as on RefSeq pages) were retrieved using UCSC Table browser:

DrugBank (CC-BY-NC/4.0 licensed) data are used for drug kinase interaction visualisations:

  • Wishart DS, Knox C, Guo AC, Shrivastava S, Hassanali M, Stothard P, Chang Z, Woolsey J. Drugbank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 2006 Jan 1;34 (Database issue):D668-72. 16381955.