39,159
Proteins
3,707,271
Mutations
18,511
Pathways
544,720
PTM sites

What is ActiveDriverDB?

ActiveDriverDB is a human proteo-genomics database. The database uses information about post-translational modifications (PTMs) in proteins to annotate and interpret genetic variation, disease genes, and cancer driver genes. All datasets in ActiveDriverDB is collected from public resources and based on experimental data. The datasets can be explored starting from some example queries (dementia mutations in MAPT, cystic fibrosis mutations in CFTR, cancer mutations in CTNNB1 phosphodegron), browsed interactively, downloaded in bulk or retrieved using an application program interface (API). Users can also upload their own custom datasets and store on the server for a limited time.

 

What's new?

This is an updated (2020) version of the ActiveDriverDB. Please see our changelog here. To access the previous (2017) version click here.

About the data

 

Post-translational modifications (PTMs) are chemical modifications of amino acids that act as molecular switches and expand the functional repertoire of proteins. Genetic changes in the protein sequence, such as mis-sense single nucleotide variants (SNVs) collected in this database, often change the sequence and structure of sites corresponding to PTMs. Further, PTMs are created and erased by certain enzymes, such as kinases that cause protein phosphorylation. These enzymes recognize specific motifs in protein sequence that may also be changed by SNVs. Thus interpreting genetic variation with protein PTMs may reveal new mechanistic details of genetic variation and protein function and help decipher genotype-phenotype associations in human variation and disease.

 

You can browse gene and pathways, ranked by PTM mutations and/or FDR:

Alternatively, you can browse all genes or all pathways.

Proteins

39,159

Kinases and other PTM enzymes

655

Kinase families

143

Mutations

3,707,271

ClinVar

318,428

TCGA MC3 1,595,400
ESP6500 1,318,972
1000 Genomes

1,066,906

Mutations in PTM sites

826,828

Mutations network-rewiring effect
(losses and gains of sequence motifs)

70,734
Total number of annotated nucleotides 96,138,347

Pathways

18,511

Kinase - site interactions 33,840
Kinases interacting with >= 1 site 497

PTM sites

544,720