After several years of serving the research community, our ActiveDriverDB database will be retired on May 1st 2026. Please make sure to download any data you need and update your links or workflows before that date.

We want to sincerely thank all our users for their support, feedback, and collaboration over the years — your contributions have been invaluable to this project. A special thank you to Dr. Michal Krassowski for leading the development of our open-source software and database.

For any questions or assistance, please contact Jüri Reimand (juri.reimand@utoronto.ca).

You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020

Pathway lists

Name Pathways count
Clinical (ClinVar, excluding somatic): all sites 999
Clinical (ClinVar, excluding somatic): acetylation sites 26
Clinical (ClinVar, excluding somatic): glycosylation sites 15
Clinical (ClinVar, excluding somatic): methylation sites 23
Clinical (ClinVar, excluding somatic): phosphorylation sites 821
Clinical (ClinVar, excluding somatic): ubiquitination sites 281
Cancer (TCGA PanCancerAtlas): all sites 761
Cancer (TCGA PanCancerAtlas): acetylation sites 165
Cancer (TCGA PanCancerAtlas): glycosylation sites 22
Cancer (TCGA PanCancerAtlas): methylation sites 64
Cancer (TCGA PanCancerAtlas): phosphorylation sites 582
Cancer (TCGA PanCancerAtlas): sumoylation sites 1
Cancer (TCGA PanCancerAtlas): ubiquitination sites 460
Cancer (PCAWG): all sites 490
Cancer (PCAWG): acetylation sites 24
Cancer (PCAWG): glycosylation sites 2
Cancer (PCAWG): methylation sites 3
Cancer (PCAWG): phosphorylation sites 363
Cancer (PCAWG): ubiquitination sites 251