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Ca-dependent events
Genes involved in this pathway:
| Gene name | Summary | # mutations | # PTM mutations | # PTM sites |
|---|---|---|---|---|
| CAMKK1 | calcium/calmodulin dependent protein kinase kinase 1 | 89 | 26 | 19 |
| PRKAR2B | protein kinase cAMP-dependent type II regulatory subunit beta | 49 | 11 | 9 |
| CAMK2B | calcium/calmodulin dependent protein kinase II beta | 92 | 48 | 39 |
| CAMK2A | calcium/calmodulin dependent protein kinase II alpha | 54 | 21 | 26 |
| PRKACA | protein kinase cAMP-activated catalytic subunit alpha | 49 | 29 | 31 |
| ADCY2 | adenylate cyclase 2 | 246 | 22 | 8 |
| MAPK1 | mitogen-activated protein kinase 1 | 41 | 30 | 35 |
| PRKAR1A | protein kinase cAMP-dependent type I regulatory subunit alpha | 143 | 93 | 34 |
| CAMKK2 | calcium/calmodulin dependent protein kinase kinase 2 | 98 | 53 | 31 |
| PRKAR2A | protein kinase cAMP-dependent type II regulatory subunit alpha | 53 | 38 | 28 |
| PDE1A | phosphodiesterase 1A | 119 | 24 | 6 |
| PLA2G4A | phospholipase A2 group IVA | 124 | 57 | 37 |
| CREB1 | cAMP responsive element binding protein 1 | 21 | 6 | 26 |
| ADCY7 | adenylate cyclase 7 | 222 | 70 | 22 |
| PDE1B | phosphodiesterase 1B | 91 | 4 | 1 |
| PRKCG | protein kinase C gamma | 156 | 25 | 14 |
| ADCY4 | adenylate cyclase 4 | 170 | 15 | 6 |
| ADCY3 | adenylate cyclase 3 | 165 | 34 | 21 |
| PRKACB | protein kinase cAMP-activated catalytic subunit beta | 42 | 31 | 35 |
| CAMK2D | calcium/calmodulin dependent protein kinase II delta | 43 | 20 | 35 |
| CAMK2G | calcium/calmodulin dependent protein kinase II gamma | 49 | 23 | 32 |
| CAMK4 | calcium/calmodulin dependent protein kinase IV | 75 | 37 | 30 |
| PRKCA | protein kinase C alpha | 81 | 46 | 51 |
| PDE1C | phosphodiesterase 1C | 214 | 22 | 9 |
| ADCY8 | adenylate cyclase 8 | 344 | 20 | 5 |
| ADCY9 | adenylate cyclase 9 | 236 | 66 | 42 |
| PRKCD | protein kinase C delta | 123 | 72 | 55 |
| ADCY1 | adenylate cyclase 1 | 183 | 12 | 9 |
| PRKACG | protein kinase cAMP-activated catalytic subunit gamma | 81 | 14 | 5 |
| GRK2 | - | - | - | - |
| ADCY5 | adenylate cyclase 5 | 204 | 11 | 6 |
| ADCY6 | adenylate cyclase 6 | 200 | 24 | 9 |
| KPNA2 | karyopherin subunit alpha 2 | 87 | 52 | 42 |
| PRKX | protein kinase X-linked | 46 | 4 | 4 |
| PRKAR1B | protein kinase cAMP-dependent type I regulatory subunit beta | 63 | 34 | 22 |
| CALM1 | calmodulin 1 | 24 | 21 | 25 |