Regulation of TP53 Activity

Genes involved in this pathway:

Gene name Summary # mutations # PTM mutations # PTM sites
XXBAC-BPG32J3.22 - - - -
CCNA2 cyclin A2 48 12 11
PRDM1 PR/SET domain 1 139 18 10
ATR ATR serine/threonine kinase 360 65 35
ZNF385A zinc finger protein 385A 47 16 7
PPP2R1B protein phosphatase 2 scaffold subunit Abeta 85 37 21
PPP1R13B protein phosphatase 1 regulatory subunit 13B 159 10 12
PRKAG3 protein kinase AMP-activated non-catalytic subunit gamma 3 107 0 0
CHEK2 checkpoint kinase 2 356 149 42
STK11 serine/threonine kinase 11 217 115 23
TAF3 TATA-box binding protein associated factor 3 119 56 46
BRD7 bromodomain containing 7 94 25 18
BLM Bloom syndrome RecQ like helicase 236 102 81
CSNK2B casein kinase 2 beta 16 5 18
EP300 E1A binding protein p300 363 126 120
SGK1 serum/glucocorticoid regulated kinase 1 57 17 9
CSNK2A2 casein kinase 2 alpha 2 29 12 12
MDM2 MDM2 proto-oncogene 53 37 47
TAF7 TATA-box binding protein associated factor 7 36 14 17
KMT5A lysine methyltransferase 5A 38 10 10
TOP3A topoisomerase (DNA) III alpha 158 11 7
RAD9A RAD9 checkpoint clamp component A 82 28 16
SETD9 SET domain containing 9 40 0 0
RFC5 replication factor C subunit 5 41 20 12
TAF6 TATA-box binding protein associated factor 6 89 27 21
RMI2 RecQ mediated genome instability 2 15 2 3
TAF9 TATA-box binding protein associated factor 9 31 18 24
DAXX death domain associated protein 120 68 56
CDKN2A cyclin dependent kinase inhibitor 2A 144 32 5
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase type 2 gamma 61 13 8
AURKA aurora kinase A 46 29 26
BANP BTG3 associated nuclear protein 64 11 9
CHD3 chromodomain helicase DNA binding protein 3 214 46 50
TAF13 TATA-box binding protein associated factor 13 13 3 2
PPP1R13L protein phosphatase 1 regulatory subunit 13 like 119 69 66
RFC2 replication factor C subunit 2 53 23 13
RFC4 replication factor C subunit 4 80 23 19
HIPK1 homeodomain interacting protein kinase 1 139 29 22
TAF5 TATA-box binding protein associated factor 5 72 0 1
CSNK2A1 casein kinase 2 alpha 1 40 28 31
BRIP1 BRCA1 interacting protein C-terminal helicase 1 455 172 46
PRR5 proline rich 5 74 18 12
RAD17 RAD17 checkpoint clamp loader component 106 18 11
RBBP7 RB binding protein 7, chromatin remodeling factor 38 13 24
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 57 9 8
MAP2K6 mitogen-activated protein kinase kinase 6 31 8 11
TTC5 tetratricopeptide repeat domain 5 64 0 1
UBB ubiquitin B 9 9 48
PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 35 9 7
PDPK1 3-phosphoinositide dependent protein kinase 1 37 17 31
SUPT16H SPT16 homolog, facilitates chromatin remodeling subunit 104 56 66
BARD1 BRCA1 associated RING domain 1 386 122 25
PRKAB1 protein kinase AMP-activated non-catalytic subunit beta 1 37 22 23
PRMT5 protein arginine methyltransferase 5 65 14 15
MLST8 MTOR associated protein, LST8 homolog 38 2 5
RNF34 ring finger protein 34 46 7 10
HUS1 HUS1 checkpoint clamp component 40 7 4
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 16 11 19
PRKAG2 protein kinase AMP-activated non-catalytic subunit gamma 2 117 61 39
AKT3 AKT serine/threonine kinase 3 63 21 15
RBBP8 RB binding protein 8, endonuclease 123 43 34
TAF4B TATA-box binding protein associated factor 4b 125 10 7
TMEM55B transmembrane protein 55B 33 4 5
BRPF3 bromodomain and PHD finger containing 3 150 40 32
USP7 ubiquitin specific peptidase 7 115 32 26
POU4F2 POU class 4 homeobox 2 99 0 0
TAF7L TATA-box binding protein associated factor 7 like 73 2 3
RBBP4 RB binding protein 4, chromatin remodeling factor 32 11 17
POU4F1 POU class 4 homeobox 1 40 1 3
TAF4 TATA-box binding protein associated factor 4 93 29 16
HDAC2 histone deacetylase 2 33 11 27
CCNG1 cyclin G1 38 0 0
CHD4 chromodomain helicase DNA binding protein 4 253 96 93
PML promyelocytic leukemia 135 41 48
MDM4 MDM4, p53 regulator 55 18 11
TP53BP2 tumor protein p53 binding protein 2 174 59 39
DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 77 9 11
L3MBTL1 L3MBTL1, histone methyl-lysine binding protein 151 3 2
MAPK14 mitogen-activated protein kinase 14 27 9 20
MTA2 metastasis associated 1 family member 2 77 35 35
TOPBP1 topoisomerase (DNA) II binding protein 1 208 52 40
EHMT2 euchromatic histone lysine methyltransferase 2 147 42 40
RFC3 replication factor C subunit 3 51 21 13
AKT1 AKT serine/threonine kinase 1 57 27 33
WRN Werner syndrome RecQ like helicase 268 55 31
TAF2 TATA-box binding protein associated factor 2 134 19 18
PPP2R1A protein phosphatase 2 scaffold subunit Aalpha 94 54 30
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase type 2 beta 45 7 10
BRD1 bromodomain containing 1 163 57 43
TAF10 TATA-box binding protein associated factor 10 20 1 5
RAD1 RAD1 checkpoint DNA exonuclease 39 4 3
KAT6A lysine acetyltransferase 6A 282 77 42
PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 98 19 13
RMI1 RecQ mediated genome instability 1 84 15 16
TAF11 TATA-box binding protein associated factor 11 27 6 3
RPS27A ribosomal protein S27a 14 13 24
UBC ubiquitin C 79 75 143
TP63 tumor protein p63 171 43 17
PPP2CA protein phosphatase 2 catalytic subunit alpha 24 16 19
PHF20 PHD finger protein 20 150 33 20
CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 24 1 3
MTOR mechanistic target of rapamycin 300 47 53
GATAD2A GATA zinc finger domain containing 2A 113 75 50
MEAF6 MYST/Esa1 associated factor 6 17 11 13
ATM ATM serine/threonine kinase 1334 230 54
TPX2 TPX2, microtubule nucleation factor 104 70 64
CDK1 cyclin dependent kinase 1 23 22 37
NUAK1 NUAK family kinase 1 114 23 12
RPA3 replication protein A3 17 1 4
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase type 2 alpha 53 10 10
RICTOR RPTOR independent companion of MTOR complex 2 193 60 99
BRPF1 bromodomain and PHD finger containing 1 148 45 37
SMYD2 SET and MYND domain containing 2 54 0 1
DNA2 DNA replication helicase/nuclease 2 136 35 22
AURKB aurora kinase B 57 38 31
MBD3 methyl-CpG binding domain protein 3 56 15 14
PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2 21 9 16
NBN nibrin 297 141 52
TP53INP1 tumor protein p53 inducible nuclear protein 1 41 0 1
RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 40 6 4
PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 63 34 39
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 18 8 14
GATAD2B GATA zinc finger domain containing 2B 77 36 33
TP53RK TP53 regulating kinase 28 11 9
CDK5 cyclin dependent kinase 5 33 13 15
SSRP1 structure specific recognition protein 1 77 59 65
NOC2L NOC2 like nucleolar associated transcriptional repressor 162 75 44
TAF1L TATA-box binding protein associated factor 1 like 467 27 7
RAD50 RAD50 double strand break repair protein 466 130 35
HDAC1 histone deacetylase 1 45 27 36
CDK2 cyclin dependent kinase 2 23 14 23
BRCA1 BRCA1, DNA repair associated 1443 532 80
EXO1 exonuclease 1 181 87 33
RAD9B RAD9 checkpoint clamp component B 63 0 1
TBP TATA-box binding protein 33 9 6
TAF9B TATA-box binding protein associated factor 9b 38 22 15
TAF12 TATA-box binding protein associated factor 12 16 6 3
EHMT1 euchromatic histone lysine methyltransferase 1 225 69 32
RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 51 9 12
MAPK11 mitogen-activated protein kinase 11 34 9 7
CHEK1 checkpoint kinase 1 55 28 34
ING5 inhibitor of growth family member 5 22 11 11
JMY junction mediating and regulatory protein, p53 cofactor 111 13 16
TAF1 TATA-box binding protein associated factor 1 232 20 28
AKT2 AKT serine/threonine kinase 2 75 27 24
RPA1 replication protein A1 83 51 48
USP2 ubiquitin specific peptidase 2 108 5 3
PLK3 polo like kinase 3 98 5 7
PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 63 15 11
ATRIP ATR interacting protein 117 23 19
ING2 inhibitor of growth family member 2 31 0 1
MRE11A MRE11 homolog, double strand break repair nuclease 280 137 51
RPA2 replication protein A2 36 23 23
MAPKAP1 mitogen-activated protein kinase associated protein 1 70 17 12
HIPK2 homeodomain interacting protein kinase 2 159 43 31
CCNA1 cyclin A1 87 0 0
PPP2CB protein phosphatase 2 catalytic subunit beta 26 14 15
KAT5 lysine acetyltransferase 5 54 19 20
TP73 tumor protein p73 106 30 14
TP53 tumor protein p53 591 443 61