After several years of serving the research community, our ActiveDriverDB database will be retired on May 1st 2026. Please make sure to download any data you need and update your links or workflows before that date.
We want to sincerely thank all our users for their support, feedback, and collaboration over the years — your contributions have been invaluable to this project. A special thank you to Dr. Michal Krassowski for leading the development of our open-source software and database.
For any questions or assistance, please contact Jüri Reimand (juri.reimand@utoronto.ca).
Reactome pathways with significant genes - Cancer (PCAWG): all sites
Following list includes Reactome pathways which have between 10 and 500 genes, including at least 5 genes predicted as significant by ActiveDriver.
The prediction bases on PTM mutations from Cancer (PCAWG): all sites dataset. Click here to see full list of top genes with PTM mutations in PCAWG.