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KDM5A (NM_001042603) - lysine demethylase 5A

Lysine-Specific Demethylase 5a

Mutations Visualisation

Protein summary

This is preferred isoform of KDM5A protein.
KDM5A: lysine-specific demethylase 5A
Description:

This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

Evidence data:
Transcript exon combination :: AB209999.1, SRR1803617.197173.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]

##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000399788.7/ ENSP00000382688.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

Strand
-
Chromosome
12
Protein
1690 residues
All mutations
227
PTM sites
73
CDS
394,621 - 498,257
Transcription
389,222 - 498,621
42.6% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 5927
UniProt
Ensembl