KDM5A (NM_001042603) - lysine demethylase 5A
Lysine-Specific Demethylase 5a
Legend
Mutation impacts
Sites
- C-linked
- N-linked
- O-linked
- S-linked
- SARS-CoV-2
Others
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Mutations Visualisation
Protein summary
This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Evidence data:
Transcript exon combination :: AB209999.1, SRR1803617.197173.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]
- Strand
- -
- Chromosome
- 12
- Protein
- 1690 residues
- All mutations
- 227
- PTM sites
- 73
- CDS
- 394,621 - 498,257
- Transcription
- 389,222 - 498,621