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PKMYT1 (NM_004203) - protein kinase, membrane associated tyrosine/threonine 1

Membrane-Associated Tyrosine- And Threonine-Specific Cdc2-Inhibitory Kinase Isoform 1

Mutations Visualisation

Protein summary

This is preferred isoform of PKMYT1 protein. View all 4 isoforms
PKMYT1: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 1
Description:

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].

Strand
-
Chromosome
16
Protein
499 residues
All mutations
92
PTM sites
37
CDS
3,022,953 - 3,029,658
Transcription
3,022,791 - 3,030,540
38.08% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 9088
UniProt
Ensembl