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TGM2 (NM_004613) - transglutaminase 2

Protein-Glutamine Gamma-Glutamyltransferase 2 Isoform A

Mutations Visualisation

Protein summary

This is preferred isoform of TGM2 protein. View all 2 isoforms
TGM2: protein-glutamine gamma-glutamyltransferase 2 isoform a
Description:

Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Strand
-
Chromosome
20
Protein
687 residues
All mutations
145
PTM sites
25
CDS
36,758,620 - 36,793,600
Transcription
36,756,863 - 36,793,700
0.29% of sequence is predicted to be disordered

External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 7052
UniProt
Ensembl