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TGM2 (NM_004613) - transglutaminase 2
Protein-Glutamine Gamma-Glutamyltransferase 2 Isoform A
Legend
Mutation impacts
direct
network-rewiring
motif-changing
proximal
distal
none
Sites
multiple types
acetylation
methylation
succinylation
sumoylation
ubiquitination
glycosylation
- C-linked
- N-linked
- O-linked
- S-linked
phosphorylation
- SARS-CoV-2
Others
Exact position of a PTM site
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Mutations Visualisation
Protein summary
This is preferred isoform of TGM2 protein.
View all 2 isoforms
TGM2:
protein-glutamine gamma-glutamyltransferase 2 isoform a
Description:
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
- Strand
- -
- Chromosome
- 20
- Protein
- 687 residues
- All mutations
- 145
- PTM sites
- 25
- CDS
- 36,758,620 - 36,793,600
- Transcription
- 36,756,863 - 36,793,700
External references
Mappings retrieved from NCBI & UniProt.