You are viewing an old version (2017) of the ActiveDriverDB. To access the new (2020) version click here.


The results shown here are in whole or part based upon data generated by the TCGA Research Network:
(as requested on

This portal uses PhosphositePlus data which is not for commercial use; please see Terms and Conditions on following page: Terms of Use and License.

Publications of databases providing essential data for ActiveDriverDB:

  • Dinkel, H. et al. Phospho.ELM: a database of phosphorylation sites--update 2011. Nucleic acids research 39, D261-267, doi:10.1093/nar/gkq1104 (2011).
  • Keshava Prasad, T. S. et al. Human Protein Reference Database--2009 update. Nucleic acids research 37, D767-772, doi:10.1093/nar/gkn892 (2009).
  • Cancer Genome Atlas Research, N. et al. The Cancer Genome Atlas Pan-Cancer analysis project. Nature genetics 45, 1113-1120, doi:10.1038/ng.2764 (2013).
  • Genomes Project, C. et al. A global reference for human genetic variation. Nature 526, 68-74, doi:10.1038/nature15393 (2015).
  • Tennessen, J. A. et al. Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science 337, 64-69, doi:10.1126/science.1219240 (2012).
  • Landrum, M. J. et al. ClinVar: public archive of relationships among sequence variation and human phenotype. Nucleic Acids Res 42, D980-985, doi:10.1093/nar/gkt1113 (2014).

We used following resources to provide external references (protein mappings):

Pathways lists are based on a gmt file retrieved from g:Profiler resource:

  • J. Reimand, T. Arak, P. Adler, L. Kolberg, S. Reisberg, H. Peterson, J. Vilo: g:Profiler -- a web server for functional interpretation of gene lists (2016 update) Nucleic Acids Research 2016; doi: 10.1093/nar/gkw199

Protein description summaries and full protein names (as on RefSeq pages) were retrieved using UCSC Table browser:

DrugBank (CC-BY-NC/4.0 licensed) data are used for drug kinase interaction visualisations:

  • Wishart DS, Knox C, Guo AC, Shrivastava S, Hassanali M, Stothard P, Chang Z, Woolsey J. Drugbank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 2006 Jan 1;34 (Database issue):D668-72. 16381955.