ActiveDriverDB'21

Find your mutation or gene of interest

Examples results:

Advanced protein search Advanced mutation search

You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020

39,159

Proteins

4,057,453

Mutations

18,537

Pathways

552,068

PTM sites

What is ActiveDriverDB?

ActiveDriverDB is a human proteo-genomics database. The database uses information about post-translational modifications (PTMs) in proteins to annotate and interpret genetic variation, disease genes, and cancer driver genes. All datasets in ActiveDriverDB is collected from public resources and based on experimental data. The datasets can be explored starting from some example queries (dementia mutations in MAPT, cystic fibrosis mutations in CFTR, cancer mutations in CTNNB1 phosphodegron), browsed interactively, downloaded in bulk or retrieved using an application program interface (API). Users can also upload their own custom datasets and store on the server for a limited time.

What's new?

This is an updated (2021) version of the ActiveDriverDB. Please see our changelog here. You can also access the previous versions: ActiveDriverDB 2020 and ActiveDriverDB 2017.

Example

Sequence

Network

TP53 (NM_000546)

Sequence | Network

PTPN11

Sequence | Network

TP53 mutations in cancer

Sequence | Network

Noonan syndrome mutations in PTPN11

Sequence | Network

About the data

Post-translational modifications (PTMs) are chemical modifications of amino acids that act as molecular switches and expand the functional repertoire of proteins. Genetic changes in the protein sequence, such as mis-sense single nucleotide variants (SNVs) collected in this database, often change the sequence and structure of sites corresponding to PTMs. Further, PTMs are created and erased by certain enzymes, such as kinases that cause protein phosphorylation. These enzymes recognize specific motifs in protein sequence that may also be changed by SNVs. Thus interpreting genetic variation with protein PTMs may reveal new mechanistic details of genetic variation and protein function and help decipher genotype-phenotype associations in human variation and disease.

You can browse gene and pathways, ranked by PTM mutations and/or FDR:

Alternatively, you can browse all genes or all pathways.

Proteins	39,159
Kinases and other PTM enzymes	662
Kinase families	147
Mutations ClinVar is hosted by the National Center for Biotechnology Information (NCBI), and is a freely accessible database of clinically significantly germilne and somatic variants. MC3 is the “Multi-Center Mutation Calling in Multiple Cancer” effort lead by The Cancer Genome Atlas (TCGA). The freely accessible MC3 dataset combines the independent mutation calling done by the Broad, Baylor, and/or Washington University. ESP6500 is part of the National Heart, Lung, and Blood Institute (NHLBI) Exome Sequencing Project (ESP), and is a multi-centre NGS project aimed at identifying new protein-coding regions associated with disorders affecting the blood, heart and lungs. 1000 Genomes is part of The International Genome Sample Resource (IGSR) effort to identify novel genetic variants in humans.	4,057,453
ClinVar	567,078
TCGA MC3	1,595,400
PCAWG	261,103
ESP6500	1,318,972
1000 Genomes	1,066,906
Mutations in PTM sites	927,313
Mutations network-rewiring effect (losses and gains of sequence motifs)	77,393
Total number of annotated nucleotides	96,105,400
Pathways	18,537
Kinase - site interactions	37,938
Kinases interacting with >= 1 site	511
PTM sites	552,068