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Mutation:
MTR R19W
Summary
Isoform:
Position:
19
Ref:
R
Mutation:
W
PTM impact:
network-rewiring
PTM affected:
2
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
[0.0154]
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 16K
Affected site:
Position: 16
Residue: K
Type: ubiquitination
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 19W | SQPEGLKKTL[R/W]RDEIN | 3 |
distal
|
| 20V | SQPEGLKKTLR[D/V]DEIN | 4 |
distal
|
PTM Site: 17T
Affected site:
Position: 17
Residue: T
Type: phosphorylation
Best loss of PTM site:
PRKCA (probability p=0.965)
Site: 17T (phosphorylation)
Position in motif: 2
There are 3 other predicted
losses:
- PRKCB (p=0.925)
- PRKCE (p=0.922)
- PRKCG (p=0.86)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 19W | QPEGLKKTL[R/W]RDEINA | 2 |
network-rewiring
|
| 20V | QPEGLKKTLR[D/V]DEINA | 3 |
distal
|
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