1. Home
  2. Mutations
  3. DMTN S92P
Login
You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:

DMTN S92P

Summary

Isoform:
NM_001114136
Position:
92
Ref:
S
Mutation:
P
PTM impact:
direct
PTM affected:
5
Kinases:
MAPK1, MAPK1

Clinical Information

Cancer types: (TCGA MC3)

KIRC

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 85S

Affected site:

Position: 85
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
82H LPRS[R/H]RERSLSPKSTS 3
distal
83Q LPRSR[E/Q]ERSLSPKSTS 2
proximal
84H LPRSRE[R/H]RSLSPKSTS 1
proximal
85L LPRSRER[S/L]SLSPKSTS 0
direct
80C LP[R/C]RSRERSLSPKSTS 5
distal

PTM Site: 90S

Affected site:

Position: 90
Residue: S
Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation In sequence Distance Impact
92F ERSLSPKST[S/F]SPPPSP 2
proximal
84H E[R/H]RSLSPKSTSPPPSP 6
distal
94Q ERSLSPKSTSP[P/Q]PPSP 4
distal
92P ERSLSPKST[S/P]SPPPSP 2
proximal
85L ER[S/L]SLSPKSTSPPPSP 5
distal

PTM Site: 91T

Affected site:

Position: 91
Residue: T
Type: phosphorylation

Best gain of PTM site:

CDK5 (probability p=0.997)
Site: 91T (phosphorylation)
Position in motif: 1
There are 8 other predicted gains:
  • MAPK9 (p=0.963)
  • GSK3B (p=0.959)
  • MAPK14 (p=0.944)
  • MAPK12 (p=0.908)
  • MAPK1 (p=0.907)
  • MAPK8 (p=0.904)
  • CDK1 (p=0.903)
  • MAPK3 (p=0.9)

Other known mutations affecting this site

Mutation In sequence Distance Impact
92F RSLSPKST[S/F]SPPPSPE 1
network-rewiring
94Q RSLSPKSTSP[P/Q]PPSPE 3
distal
92P RSLSPKST[S/P]SPPPSPE 1
network-rewiring
85L R[S/L]SLSPKSTSPPPSPE 6
distal

PTM Site: 92S

Affected site:

Position: 92
Residue: S
Type: phosphorylation

Impact:

direct

Other known mutations affecting this site

Mutation In sequence Distance Impact
92F SLSPKST[S/F]SPPPSPEV 0
direct
94Q SLSPKSTSP[P/Q]PPSPEV 2
proximal
92P SLSPKST[S/P]SPPPSPEV 0
direct

PTM Site: 96S

Affected site:

Position: 96
Residue: S
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
92F KST[S/F]SPPPSPEVWADS 4
distal
94Q KSTSP[P/Q]PPSPEVWADS 2
proximal
92P KST[S/P]SPPPSPEVWADS 4
distal

If you have any questions or feedback about this mutation:

Contact us