You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:
TP53 R116W
Summary
Isoform:
Position:
116
Ref:
R
Mutation:
W
PTM impact:
proximal
PTM affected:
1
Kinases:
CDK4
Clinical Information
Cancer types: (TCGA MC3)
GBM, OV, LUSC, SARC, CHOL, UCEC, COAD, BRCA, HNSC, LIHC, BLCA, READ, LGG, SKCM, PAAD, STAD, ESCA, LUAD, UCS, DLBC, PRAD
Cancer types: (PCAWG)
Eso-AdenoCa, Head-SCC, Ovary-AdenoCA, Bladder-TCC, Uterus-AdenoCA, Panc-AdenoCA, Breast-LobularCa, Prost-AdenoCA, Liver-HCC, ColoRect-AdenoCA, Breast-AdenoCa, Bone-Osteosarc
Disease Annotations: (ClinVar)
Li-Fraumeni syndrome, Pectus excavatum, Hereditary cancer-predisposing syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 117R
Affected site:
Position: 117
Residue: R
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
External references
dbSNP:
If you have any questions or feedback about this mutation:
Contact us