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Mutation:
CANT1 D141V
Summary
Isoform:
Position:
141
Ref:
D
Mutation:
V
PTM impact:
network-rewiring
PTM affected:
2
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
[0.0154]
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 137S
Affected site:
Position: 137
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 141V | KKGYLTLSDSG[D/V]DKVA | 4 |
distal
|
| 140E | KKGYLTLSDS[G/E]GDKVA | 3 |
network-rewiring
|
| 131R | K[K/R]KGYLTLSDSGDKVA | 6 |
distal
|
PTM Site: 139S
Affected site:
Position: 139
Residue: S
Type: phosphorylation
Only loss of PTM site:
CAMK2A (probability p=0.93)
Site: 139S (phosphorylation)
Position in motif: 2
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 145L | GYLTLSDSGDKVA[V/L]VE | 6 |
distal
|
| 141V | GYLTLSDSG[D/V]DKVAVE | 2 |
network-rewiring
|
| 140E | GYLTLSDS[G/E]GDKVAVE | 1 |
proximal
|
| 144T | GYLTLSDSGDKV[A/T]AVE | 5 |
distal
|
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