MEF2C P398A

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Mutation:

Summary

Isoform:

NM_001193348

Position:

398

Ref:

Mutation:

PTM impact:

network-rewiring

PTM affected:

Kinases:

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

[0.0199681]

PTM Site: 397S

Affected site:

Position: 397

Residue: S

Type: phosphorylation

Best loss of PTM site:

MAPK3 (probability p=0.938)

Site: 397S (phosphorylation)

Position in motif: 1

There are 6 other predicted losses:

MAPK1 (p=0.919)
CDK1 (p=0.907)
MAPK14 (p=0.899)
MAPK9 (p=0.882)
MAPK8 (p=0.881)
CDK2 (p=0.853)

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
398A	PIGLTRPS[P/A]PDERESP	1	network-rewiring
400K	PIGLTRPSPD[E/K]ERESP	3	network-rewiring
395K	PIGLT[R/K]RPSPDERESP	2	network-rewiring
401T	PIGLTRPSPDE[R/T]RESP	4	distal
401K	PIGLTRPSPDE[R/K]RESP	4	distal

PTM Site: 403S

Affected site:

Position: 403

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
406A	PSPDERESPS[V/A]VKRMR	3	distal
398A	PS[P/A]PDERESPSVKRMR	5	distal
400K	PSPD[E/K]ERESPSVKRMR	3	network-rewiring
401T	PSPDE[R/T]RESPSVKRMR	2	network-rewiring
401K	PSPDE[R/K]RESPSVKRMR	2	network-rewiring

PTM Site: 405S

Affected site:

Position: 405

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
406A	PDERESPS[V/A]VKRMRLS	1	proximal
400K	PD[E/K]ERESPSVKRMRLS	5	distal
401T	PDE[R/T]RESPSVKRMRLS	4	distal
401K	PDE[R/K]RESPSVKRMRLS	4	distal

If you have any questions or feedback about this mutation: