PDE3A D230V

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Mutation:

Summary

Isoform:

NM_001244683

Position:

230

Ref:

Mutation:

PTM impact:

proximal

PTM affected:

Kinases:

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

[0.0077]

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 228S

Affected site:

Position: 228

Residue: S

Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
230V	SAVQFPESA[D/V]DTTAKQ	2	proximal
224E	SAV[Q/E]QFPESADTTAKQ	4	distal
227Q	SAVQFP[E/Q]ESADTTAKQ	1	proximal

PTM Site: 231T

Affected site:

Position: 231

Residue: T

Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
230V	QFPESA[D/V]DTTAKQSLG	1	proximal
237R	QFPESADTTAKQS[L/R]LG	6	distal
227Q	QFP[E/Q]ESADTTAKQSLG	4	distal

PTM Site: 232T

Affected site:

Position: 232

Residue: T

Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
230V	FPESA[D/V]DTTAKQSLGS	2	proximal
237R	FPESADTTAKQS[L/R]LGS	5	distal
227Q	FP[E/Q]ESADTTAKQSLGS	5	distal

PTM Site: 234K

Affected site:

Position: 234

Residue: K

Type: ubiquitination

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
230V	ESA[D/V]DTTAKQSLGSHR	4	distal
237R	ESADTTAKQS[L/R]LGSHR	3	distal

PTM Site: 236S

Affected site:

Position: 236

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
230V	A[D/V]DTTAKQSLGSHRAL	6	distal
237R	ADTTAKQS[L/R]LGSHRAL	1	proximal

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