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Mutation:
ANKRD11 D847N
Summary
Isoform:
Position:
847
Ref:
D
Mutation:
N
PTM impact:
network-rewiring
PTM affected:
4
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
COAD
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
[0.0199681]
PTM Site: 843S
Affected site:
Position: 843
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 840W | DQRD[R/W]RWFSDLSDSSF | 3 |
network-rewiring
|
| 840Q | DQRD[R/Q]RWFSDLSDSSF | 3 |
network-rewiring
|
| 847N | DQRDRWFSDLS[D/N]DSSF | 4 |
distal
|
PTM Site: 846S
Affected site:
Position: 846
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 840W | D[R/W]RWFSDLSDSSFDFK | 6 |
distal
|
| 840Q | D[R/Q]RWFSDLSDSSFDFK | 6 |
distal
|
| 847N | DRWFSDLS[D/N]DSSFDFK | 1 |
proximal
|
| 852L | DRWFSDLSDSSFD[F/L]FK | 6 |
distal
|
PTM Site: 848S
Affected site:
Position: 848
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 847N | WFSDLS[D/N]DSSFDFKGE | 1 |
proximal
|
| 852L | WFSDLSDSSFD[F/L]FKGE | 4 |
distal
|
PTM Site: 849S
Affected site:
Position: 849
Residue: S
Type: phosphorylation
Only loss of PTM site:
PLK1 (probability p=0.856)
Site: 849S (phosphorylation)
Position in motif: -2
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 847N | FSDLS[D/N]DSSFDFKGED | 2 |
network-rewiring
|
| 852L | FSDLSDSSFD[F/L]FKGED | 3 |
distal
|
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