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Mutation:
TRO M221I
Summary
Isoform:
Position:
221
Ref:
M
Mutation:
I
PTM impact:
proximal
PTM affected:
2
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
BLCA
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 220K
Affected site:
Position: 220
Residue: K
Type: ubiquitination
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 222R | RSYHETSKM[K/R]KVLKFA | 2 |
proximal
|
| 214P | R[S/P]SYHETSKMKVLKFA | 6 |
distal
|
| 223I | RSYHETSKMK[V/I]VLKFA | 3 |
distal
|
| 221I | RSYHETSK[M/I]MKVLKFA | 1 |
proximal
|
PTM Site: 225K
Affected site:
Position: 225
Residue: K
Type: ubiquitination
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 222R | TSKM[K/R]KVLKFACRVQK | 3 |
distal
|
| 223I | TSKMK[V/I]VLKFACRVQK | 2 |
proximal
|
| 221I | TSK[M/I]MKVLKFACRVQK | 4 |
distal
|
| 230L | TSKMKVLKFACR[V/L]VQK | 5 |
distal
|
| 230M | TSKMKVLKFACR[V/M]VQK | 5 |
distal
|
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