You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:
ACBD5 P171L
Summary
Isoform:
Position:
171
Ref:
P
Mutation:
L
PTM impact:
network-rewiring
PTM affected:
1
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
[0.0077]
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 170T
Affected site:
Position: 170
Residue: T
Type: phosphorylation
Best loss of PTM site:
MAPK1 (probability p=0.933)
Site: 170T (phosphorylation)
Position in motif: 1
There are 4 other predicted
losses:
- MAPK3 (p=0.929)
- CDK1 (p=0.902)
- MAPK14 (p=0.901)
- CDK2 (p=0.898)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 176I | LGNVLTSTPNAKT[V/I]VN | 6 |
distal
|
| 172D | LGNVLTSTP[N/D]NAKTVN | 2 |
proximal
|
| 171L | LGNVLTST[P/L]PNAKTVN | 1 |
network-rewiring
|
| 173T | LGNVLTSTPN[A/T]AKTVN | 3 |
distal
|
| 168I | LGNVL[T/I]TSTPNAKTVN | 2 |
proximal
|
| 176F | LGNVLTSTPNAKT[V/F]VN | 6 |
distal
|
If you have any questions or feedback about this mutation:
Contact us