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Mutation:
ACBD5 D184Y
Summary
Isoform:
Position:
184
Ref:
D
Mutation:
Y
PTM impact:
network-rewiring
PTM affected:
4
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
Eso-AdenoCa
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 182S
Affected site:
Position: 182
Residue: S
Type: phosphorylation
Only loss of PTM site:
CAMK2A (probability p=0.897)
Site: 182S (phosphorylation)
Position in motif: 2
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 176I | T[V/I]VNGKAESSDSGAES | 6 |
distal
|
| 188K | TVNGKAESSDSGA[E/K]ES | 6 |
distal
|
| 176F | T[V/F]VNGKAESSDSGAES | 6 |
distal
|
| 184Y | TVNGKAESS[D/Y]DSGAES | 2 |
network-rewiring
|
PTM Site: 183S
Affected site:
Position: 183
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 188K | VNGKAESSDSGA[E/K]ESE | 5 |
distal
|
| 184Y | VNGKAESS[D/Y]DSGAESE | 1 |
proximal
|
PTM Site: 185S
Affected site:
Position: 185
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 188K | GKAESSDSGA[E/K]ESEEE | 3 |
network-rewiring
|
| 184Y | GKAESS[D/Y]DSGAESEEE | 1 |
proximal
|
PTM Site: 189S
Affected site:
Position: 189
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 188K | SSDSGA[E/K]ESEEEEAQE | 1 |
proximal
|
| 184Y | SS[D/Y]DSGAESEEEEAQE | 5 |
distal
|
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