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Mutation:
TEX2 E198K
Summary
Isoform:
Position:
198
Ref:
E
Mutation:
K
PTM impact:
network-rewiring
PTM affected:
4
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
[0.0199681]
PTM Site: 194S
Affected site:
Position: 194
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 198K | PFMSLVKSLST[E/K]EVEP | 4 |
distal
|
PTM Site: 196S
Affected site:
Position: 196
Residue: S
Type: phosphorylation
Best gain of PTM site:
PRKCA (probability p=0.92)
Site: 196S (phosphorylation)
Position in motif: 2
There are 2 other predicted
gains:
- PRKCB (p=0.906)
- PRKCG (p=0.864)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 202N | MSLVKSLSTEVEP[K/N]KE | 6 |
distal
|
| 198K | MSLVKSLST[E/K]EVEPKE | 2 |
network-rewiring
|
PTM Site: 197T
Affected site:
Position: 197
Residue: T
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 202N | SLVKSLSTEVEP[K/N]KES | 5 |
distal
|
| 198K | SLVKSLST[E/K]EVEPKES | 1 |
proximal
|
PTM Site: 204S
Affected site:
Position: 204
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 202N | TEVEP[K/N]KESPHPARHR | 2 |
proximal
|
| 198K | T[E/K]EVEPKESPHPARHR | 6 |
distal
|
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