You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:
MDM2 E298K
Summary
Isoform:
Position:
298
Ref:
E
Mutation:
K
PTM impact:
network-rewiring
PTM affected:
3
Kinases:
CSNK1D
Clinical Information
Cancer types: (TCGA MC3)
BRCA
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 292S
Affected site:
Position: 292
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 288H | TVY[Q/H]QAGESDTDSFEE | 4 |
distal
|
| 298K | TVYQAGESDTDSF[E/K]EE | 6 |
distal
|
| 290W | TVYQA[G/W]GESDTDSFEE | 2 |
proximal
|
PTM Site: 294T
Affected site:
Position: 294
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 288H | Y[Q/H]QAGESDTDSFEEDP | 6 |
distal
|
| 298K | YQAGESDTDSF[E/K]EEDP | 4 |
distal
|
| 290W | YQA[G/W]GESDTDSFEEDP | 4 |
distal
|
PTM Site: 296S
Affected site:
Position: 296
Residue: S
Type: phosphorylation
Only gain of PTM site:
PRKCA (probability p=0.921)
Site: 296S (phosphorylation)
Position in motif: 2
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 298K | AGESDTDSF[E/K]EEDPEI | 2 |
network-rewiring
|
| 290W | A[G/W]GESDTDSFEEDPEI | 6 |
distal
|
If you have any questions or feedback about this mutation:
Contact us