COPA D180H

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Mutation:

Summary

Isoform:

NM_004371

Position:

180

Ref:

Mutation:

PTM impact:

proximal

PTM affected:

Kinases:

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

[0.0199681]

PTM Site: 173S

Affected site:

Position: 173

Residue: S

Type: phosphorylation, phosphorylation (SARS-CoV-2)

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
170R	GLRK[K/R]KNLSPGAVESD	3	network-rewiring
176V	GLRKKNLSPG[A/V]AVESD	3	distal

PTM Site: 179S

Affected site:

Position: 179

Residue: S

Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
176V	LSPG[A/V]AVESDVRGITG	3	distal
180H	LSPGAVES[D/H]DVRGITG	1	proximal

PTM Site: 182R

Affected site:

Position: 182

Residue: R

Type: methylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
188V	GAVESDVRGITGV[D/V]DL	6	distal
176V	G[A/V]AVESDVRGITGVDL	6	distal
180H	GAVES[D/H]DVRGITGVDL	2	proximal
188N	GAVESDVRGITGV[D/N]DL	6	distal

PTM Site: 185T

Affected site:

Position: 185

Residue: T

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
188V	ESDVRGITGV[D/V]DLFGT	3	distal
180H	ES[D/H]DVRGITGVDLFGT	5	distal
188N	ESDVRGITGV[D/N]DLFGT	3	distal

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