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Mutation:
MPP2 C310R
Summary
Isoform:
Position:
310
Ref:
C
Mutation:
R
PTM impact:
network-rewiring
PTM affected:
3
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
[0.0077]
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 303T
Affected site:
Position: 303
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 303A | VKRDLEL[T/A]TPNSGTLC | 0 |
direct
|
PTM Site: 312S
Affected site:
Position: 312
Residue: S
Type: phosphorylation
Best gain of PTM site:
AURKA (probability p=0.984)
Site: 312S (phosphorylation)
Position in motif: -2
There are 4 other predicted
gains:
- PRKACA (p=0.952)
- PRKCD (p=0.931)
- ROCK1 (p=0.882)
- AURKB (p=0.881)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 311S | NSGTLC[G/S]GSLSGKKKK | 1 |
proximal
|
| 310R | NSGTL[C/R]CGSLSGKKKK | 2 |
network-rewiring
|
| 315E | NSGTLCGSLS[G/E]GKKKK | 3 |
network-rewiring
|
PTM Site: 314S
Affected site:
Position: 314
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 311S | GTLC[G/S]GSLSGKKKKRM | 3 |
distal
|
| 310R | GTL[C/R]CGSLSGKKKKRM | 4 |
distal
|
| 320Q | GTLCGSLSGKKKK[R/Q]RM | 6 |
distal
|
| 315E | GTLCGSLS[G/E]GKKKKRM | 1 |
proximal
|
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