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Mutation:
DDR2 R742Q
Summary
Isoform:
Position:
742
Ref:
R
Mutation:
Q
PTM impact:
proximal
PTM affected:
3
Kinases:
SRC,
SRC,
SRC
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
[0.0199681]
PTM Site: 736Y
Affected site:
Position: 736
Residue: Y
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 740C | FGMSRNLYSGD[Y/C]YYRI | 4 |
distal
|
| 737R | FGMSRNLY[S/R]SGDYYRI | 1 |
proximal
|
| 742W | FGMSRNLYSGDYY[R/W]RI | 6 |
distal
|
| 742Q | FGMSRNLYSGDYY[R/Q]RI | 6 |
distal
|
PTM Site: 740Y
Affected site:
Position: 740
Residue: Y
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 740C | RNLYSGD[Y/C]YYRIQGRA | 0 |
direct
|
| 746Q | RNLYSGDYYRIQG[R/Q]RA | 6 |
distal
|
| 737R | RNLY[S/R]SGDYYRIQGRA | 3 |
distal
|
| 742W | RNLYSGDYY[R/W]RIQGRA | 2 |
proximal
|
| 742Q | RNLYSGDYY[R/Q]RIQGRA | 2 |
proximal
|
PTM Site: 741Y
Affected site:
Position: 741
Residue: Y
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 740C | NLYSGD[Y/C]YYRIQGRAV | 1 |
proximal
|
| 746Q | NLYSGDYYRIQG[R/Q]RAV | 5 |
distal
|
| 737R | NLY[S/R]SGDYYRIQGRAV | 4 |
distal
|
| 742W | NLYSGDYY[R/W]RIQGRAV | 1 |
proximal
|
| 742Q | NLYSGDYY[R/Q]RIQGRAV | 1 |
proximal
|
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