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Mutation:
ARFGEF2 P219H
Summary
Isoform:
Position:
219
Ref:
P
Mutation:
H
PTM impact:
network-rewiring
PTM affected:
2
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
STAD
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 214S
Affected site:
Position: 214
Residue: S
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 209K | EL[E/K]EKPIQSKPQSPVI | 5 |
distal
|
| 212L | ELEKP[I/L]IQSKPQSPVI | 2 |
proximal
|
| 219H | ELEKPIQSKPQS[P/H]PVI | 5 |
distal
|
PTM Site: 218S
Affected site:
Position: 218
Residue: S
Type: phosphorylation (SARS-CoV-2), phosphorylation
Best loss of PTM site:
MAPK3 (probability p=0.996)
Site: 218S (phosphorylation, phosphorylation (SARS-CoV-2))
Position in motif: 1
There are 9 other predicted
losses:
- MAPK14 (p=0.959)
- MAPK8 (p=0.958)
- MAPK1 (p=0.954)
- GSK3B (p=0.953)
- MAPK9 (p=0.943)
- MAPK11 (p=0.942)
- CDK2 (p=0.93)
- CDK1 (p=0.916)
- CDK4 (p=0.913)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 212L | P[I/L]IQSKPQSPVIQAAA | 6 |
distal
|
| 219H | PIQSKPQS[P/H]PVIQAAA | 1 |
network-rewiring
|
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