BRCA1 S434G

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Mutation:

Isoform:

NM_007300

Position:

434

Ref:

Mutation:

PTM impact:

direct

PTM affected:

Kinases:

no data

no data

Hereditary cancer-predisposing syndrome

no data

no data

Position: 428

Residue: K

Type: ubiquitination

distal

Mutation	In sequence	Distance	Impact
434N	EYSGSSEKIDLLA[S/N]SD	6	distal
434G	EYSGSSEKIDLLA[S/G]SD	6	distal
434R	EYSGSSEKIDLLA[S/R]SD	6	distal
432P	EYSGSSEKIDL[L/P]LASD	4	distal
432M	EYSGSSEKIDL[L/M]LASD	4	distal
431I	EYSGSSEKID[L/I]LLASD	3	distal
430G	EYSGSSEKI[D/G]DLLASD	2	proximal
429R	EYSGSSEK[I/R]IDLLASD	1	proximal
429T	EYSGSSEK[I/T]IDLLASD	1	proximal
424R	EYS[G/R]GSSEKIDLLASD	4	distal
424S	EYS[G/S]GSSEKIDLLASD	4	distal
422F	E[Y/F]YSGSSEKIDLLASD	6	distal
422C	E[Y/C]YSGSSEKIDLLASD	6	distal
422H	E[Y/H]YSGSSEKIDLLASD	6	distal

Position: 434

Residue: S

Type: phosphorylation

direct

Mutation	In sequence	Distance	Impact
440S	EKIDLLASDPHEA[L/S]LI	6	distal
439G	EKIDLLASDPHE[A/G]ALI	5	distal
439S	EKIDLLASDPHE[A/S]ALI	5	distal
439T	EKIDLLASDPHE[A/T]ALI	5	distal
437R	EKIDLLASDP[H/R]HEALI	3	distal
437P	EKIDLLASDP[H/P]HEALI	3	distal
437Y	EKIDLLASDP[H/Y]HEALI	3	distal
434N	EKIDLLA[S/N]SDPHEALI	0	direct
434G	EKIDLLA[S/G]SDPHEALI	0	direct
434R	EKIDLLA[S/R]SDPHEALI	0	direct
432P	EKIDL[L/P]LASDPHEALI	2	proximal
432M	EKIDL[L/M]LASDPHEALI	2	proximal
431I	EKID[L/I]LLASDPHEALI	3	distal
430G	EKI[D/G]DLLASDPHEALI	4	distal
429R	EK[I/R]IDLLASDPHEALI	5	network-rewiring
429T	EK[I/T]IDLLASDPHEALI	5	distal

dbSNP:

rs786203753

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