TRIM29 G11R

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Mutation:

Summary

Isoform:

NM_012101

Position:

Ref:

Mutation:

PTM impact:

network-rewiring

PTM affected:

Kinases:

Clinical Information

Cancer types: (TCGA MC3)

GBM

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

no data

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 7S

Affected site:

Position: 7

Residue: S

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
11R	-MEAADASRSN[G/R]GSSP	4	distal
7P	-MEAADA[S/P]SRSNGSSP	0	direct

PTM Site: 9S

Affected site:

Position: 9

Residue: S

Type: phosphorylation

Best gain of PTM site:

PRKCE (probability p=0.991)

Site: 9S (phosphorylation)

Position in motif: 2

There are 7 other predicted gains:

PRKCA (p=0.966)
PRKACA (p=0.963)
PRKCG (p=0.956)
AURKA (p=0.943)
PRKCB (p=0.943)
PRKCD (p=0.924)
AURKB (p=0.906)

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
11R	EAADASRSN[G/R]GSSPEA	2	network-rewiring
7P	EAADA[S/P]SRSNGSSPEA	2	proximal

PTM Site: 12S

Affected site:

Position: 12

Residue: S

Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
11R	DASRSN[G/R]GSSPEARDA	1	proximal
7P	DA[S/P]SRSNGSSPEARDA	5	distal

PTM Site: 13S

Affected site:

Position: 13

Residue: S

Type: phosphorylation

Best gain of PTM site:

PRKCE (probability p=0.991)

Site: 9S (phosphorylation)

Position in motif: 2

There are 7 other predicted gains:

PRKCA (p=0.966)
PRKACA (p=0.963)
PRKCG (p=0.956)
AURKA (p=0.943)
PRKCB (p=0.943)
PRKCD (p=0.924)
AURKB (p=0.906)

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
11R	ASRSN[G/R]GSSPEARDAR	2	network-rewiring
7P	A[S/P]SRSNGSSPEARDAR	6	distal

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