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Mutation:
NCKAP1 R149P
Summary
Isoform:
Position:
149
Ref:
R
Mutation:
P
PTM impact:
network-rewiring
PTM affected:
2
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
UCS
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 142T
Affected site:
Position: 142
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 141R | DLIITY[T/R]TTLMILLSR | 1 |
proximal
|
| 137S | DL[I/S]IITYTTLMILLSR | 5 |
distal
|
Showing 1 to 2 of 2 rows
PTM Site: 148S
Affected site:
Position: 148
Residue: S
Type: phosphorylation
Best gain of PTM site:
MAPK1 (probability p=0.957)
Site: 148S (phosphorylation)
Position in motif: 1
There are 8 other predicted
gains:
- MAPK8 (p=0.955)
- MAPK3 (p=0.954)
- MAPK14 (p=0.942)
- MAPK9 (p=0.892)
- CDK1 (p=0.882)
- CDK2 (p=0.881)
- MAPK11 (p=0.864)
- GSK3B (p=0.864)
Other known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 149P | TTLMILLS[R/P]RIEERKA | 1 |
network-rewiring
|
| 154R | TTLMILLSRIEER[K/R]KA | 6 |
distal
|
Showing 1 to 2 of 2 rows
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