You are viewing an updated version (2021) of the ActiveDriverDB. To view the previous version please visit activedriverdb.org/v2020
Mutation:
WNK1 T74A
Summary
Clinical Information
Cancer types: (TCGA MC3)
BLCA
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 72T
Affected site:
Position: 72
Residue: T
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 68T | SRG[A/T]AAATTTTTEHRF | 4 |
distal
|
| 70G | SRGAA[A/G]ATTTTTEHRF | 2 |
proximal
|
| 72A | SRGAAAT[T/A]TTTTEHRF | 0 |
direct
|
| 73A | SRGAAATT[T/A]TTTEHRF | 1 |
proximal
|
| 74A | SRGAAATTT[T/A]TTEHRF | 2 |
proximal
|
PTM Site: 74T
Affected site:
Position: 74
Residue: T
Type: phosphorylation
Impact:
directOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 68T | G[A/T]AAATTTTTEHRFFR | 6 |
distal
|
| 70G | GAA[A/G]ATTTTTEHRFFR | 4 |
distal
|
| 72A | GAAAT[T/A]TTTTEHRFFR | 2 |
proximal
|
| 73A | GAAATT[T/A]TTTEHRFFR | 1 |
proximal
|
| 74A | GAAATTT[T/A]TTEHRFFR | 0 |
direct
|
PTM Site: 75T
Affected site:
Position: 75
Residue: T
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 70G | AA[A/G]ATTTTTEHRFFRR | 5 |
distal
|
| 72A | AAAT[T/A]TTTTEHRFFRR | 3 |
distal
|
| 73A | AAATT[T/A]TTTEHRFFRR | 2 |
proximal
|
| 81P | AAATTTTTEHRFF[R/P]RR | 6 |
distal
|
| 74A | AAATTT[T/A]TTEHRFFRR | 1 |
proximal
|
If you have any questions or feedback about this mutation:
Contact us