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Mutation:
SERPINB12 L35P
Summary
Isoform:
Position:
35
Ref:
L
Mutation:
P
PTM impact:
network-rewiring
PTM affected:
2
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
ACC
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 34S
Affected site:
Position: 34
Residue: S
Type: phosphorylation
Best gain of PTM site:
MAPK3 (probability p=0.997)
Site: 34S (phosphorylation)
Position in motif: 1
There are 10 other predicted
gains:
- MAPK14 (p=0.979)
- MAPK9 (p=0.961)
- MAPK8 (p=0.959)
- CDK2 (p=0.952)
- MAPK11 (p=0.939)
- CDK1 (p=0.92)
- MAPK1 (p=0.908)
- GSK3B (p=0.904)
- CDK4 (p=0.887)
- CDK5 (p=0.871)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 28L | N[I/L]IFFSPLSLSAALGM | 6 |
distal
|
| 38P | NIFFSPLSLSA[A/P]ALGM | 4 |
distal
|
| 34N | NIFFSPL[S/N]SLSAALGM | 0 |
direct
|
| 40S | NIFFSPLSLSAAL[G/S]GM | 6 |
distal
|
| 33P | NIFFSP[L/P]LSLSAALGM | 1 |
proximal
|
| 35P | NIFFSPLS[L/P]LSAALGM | 1 |
network-rewiring
|
PTM Site: 36S
Affected site:
Position: 36
Residue: S
Type: phosphorylation
Impact:
proximalOther known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 38P | FFSPLSLSA[A/P]ALGMVR | 2 |
proximal
|
| 34N | FFSPL[S/N]SLSAALGMVR | 2 |
proximal
|
| 40S | FFSPLSLSAAL[G/S]GMVR | 4 |
distal
|
| 41I | FFSPLSLSAALG[M/I]MVR | 5 |
distal
|
| 33P | FFSP[L/P]LSLSAALGMVR | 3 |
distal
|
| 35P | FFSPLS[L/P]LSAALGMVR | 1 |
proximal
|
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