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Mutation:
KRT79 S59R
Summary
Isoform:
Position:
59
Ref:
S
Mutation:
R
PTM impact:
network-rewiring
PTM affected:
1
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
[0.0199681]
PTM Site: 61S
Affected site:
Position: 61
Residue: S
Type: phosphorylation
Best gain of PTM site:
AURKA (probability p=0.973)
Site: 61S (phosphorylation)
Position in motif: -2
There are 4 other predicted
gains:
- PRKACA (p=0.948)
- AURKB (p=0.935)
- PRKCD (p=0.916)
- ROCK1 (p=0.881)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 64K | TGGFGSRSLY[N/K]NLGGH | 3 |
distal
|
| 59R | TGGFG[S/R]SRSLYNLGGH | 2 |
network-rewiring
|
| 56S | TG[G/S]GFGSRSLYNLGGH | 5 |
distal
|
| 61N | TGGFGSR[S/N]SLYNLGGH | 0 |
direct
|
| 66R | TGGFGSRSLYNL[G/R]GGH | 5 |
distal
|
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