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Mutation:
NAV2 R1585Q
Summary
Isoform:
Position:
1585
Ref:
R
Mutation:
Q
PTM impact:
network-rewiring
PTM affected:
3
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
[0.0077]
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 1587S
Affected site:
Position: 1587
Residue: S
Type: phosphorylation
Best loss of PTM site:
RPS6KA1 (probability p=0.998)
Site: 1588S (phosphorylation)
Position in motif: -3
There are 12 other predicted
losses:
- AKT2 (p=0.98)
- PRKACA (p=0.963)
- PRKACA (p=0.94)
- PRKCD (p=0.936)
- CAMK2A (p=0.931)
- PAK1 (p=0.905)
- AKT1 (p=0.894)
- ROCK1 (p=0.887)
- PRKCD (p=0.885)
- CAMK4 (p=0.882)
- PRKAA1 (p=0.882)
- AURKB (p=0.871)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 1583C | TDS[R/C]RFRNSSMSLDEK | 4 |
distal
|
| 1585W | TDSRF[R/W]RNSSMSLDEK | 2 |
network-rewiring
|
| 1585Q | TDSRF[R/Q]RNSSMSLDEK | 2 |
network-rewiring
|
| 1583H | TDS[R/H]RFRNSSMSLDEK | 4 |
distal
|
PTM Site: 1588S
Affected site:
Position: 1588
Residue: S
Type: phosphorylation
Best loss of PTM site:
RPS6KA1 (probability p=0.998)
Site: 1588S (phosphorylation)
Position in motif: -3
There are 12 other predicted
losses:
- AKT2 (p=0.98)
- PRKACA (p=0.963)
- PRKACA (p=0.94)
- PRKCD (p=0.936)
- CAMK2A (p=0.931)
- PAK1 (p=0.905)
- AKT1 (p=0.894)
- ROCK1 (p=0.887)
- PRKCD (p=0.885)
- CAMK4 (p=0.882)
- PRKAA1 (p=0.882)
- AURKB (p=0.871)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 1583C | DS[R/C]RFRNSSMSLDEKS | 5 |
distal
|
| 1585W | DSRF[R/W]RNSSMSLDEKS | 3 |
network-rewiring
|
| 1585Q | DSRF[R/Q]RNSSMSLDEKS | 3 |
network-rewiring
|
| 1583H | DS[R/H]RFRNSSMSLDEKS | 5 |
distal
|
PTM Site: 1590S
Affected site:
Position: 1590
Residue: S
Type: phosphorylation
Best loss of PTM site:
RPS6KA1 (probability p=0.998)
Site: 1588S (phosphorylation)
Position in motif: -3
There are 12 other predicted
losses:
- AKT2 (p=0.98)
- PRKACA (p=0.963)
- PRKACA (p=0.94)
- PRKCD (p=0.936)
- CAMK2A (p=0.931)
- PAK1 (p=0.905)
- AKT1 (p=0.894)
- ROCK1 (p=0.887)
- PRKCD (p=0.885)
- CAMK4 (p=0.882)
- PRKAA1 (p=0.882)
- AURKB (p=0.871)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 1585W | RF[R/W]RNSSMSLDEKSRT | 5 |
network-rewiring
|
| 1585Q | RF[R/Q]RNSSMSLDEKSRT | 5 |
network-rewiring
|
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