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Mutation:
ACACA P699L
Summary
Isoform:
Position:
699
Ref:
P
Mutation:
L
PTM impact:
network-rewiring
PTM affected:
1
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
SKCM
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 698S
Affected site:
Position: 698
Residue: S
Type: phosphorylation
Best loss of PTM site:
MAPK1 (probability p=0.95)
Site: 698S (phosphorylation)
Position in motif: 1
There are 7 other predicted
losses:
- MAPK3 (p=0.949)
- MAPK8 (p=0.943)
- GSK3B (p=0.942)
- CDK5 (p=0.935)
- MAPK9 (p=0.926)
- CDK2 (p=0.898)
- CDK1 (p=0.891)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 701S | NDPSVMRSPS[A/S]AGKLI | 3 |
distal
|
| 699L | NDPSVMRS[P/L]PSAGKLI | 1 |
network-rewiring
|
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