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Mutation:
LARP4 R309K
Summary
Isoform:
Position:
309
Ref:
R
Mutation:
K
PTM impact:
network-rewiring
PTM affected:
2
Kinases:
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
Liver-HCC
Disease Annotations: (ClinVar)
no data
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 311S
Affected site:
Position: 311
Residue: S
Type: phosphorylation
Best loss of PTM site:
PRKACA (probability p=0.943)
Site: 311S (phosphorylation)
Position in motif: -2
There are 2 other predicted
losses:
- AKT1 (p=0.931)
- PRKCD (p=0.899)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 309K | VKPQF[R/K]RSSGGSEHST | 2 |
network-rewiring
|
PTM Site: 314S
Affected site:
Position: 314
Residue: S
Type: phosphorylation
Best loss of PTM site:
PRKACA (probability p=0.943)
Site: 311S (phosphorylation)
Position in motif: -2
There are 2 other predicted
losses:
- AKT1 (p=0.931)
- PRKCD (p=0.899)
Other known mutations affecting this site
| Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 318A | QFRSSGGSEHS[T/A]TEGS | 4 |
distal
|
| 309K | QF[R/K]RSSGGSEHSTEGS | 5 |
network-rewiring
|
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