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RUNX1 (NM_001001890) - RUNX family transcription factor 1

Runt-Related Transcription Factor 1 Isoform Aml1b

PTM Interaction Network Visualisation

Protein summary

This is preferred isoform of RUNX1 protein. View all 3 isoforms
RUNX1: runt-related transcription factor 1 isoform AML1b
Description:

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Strand
-
Chromosome
21
Protein
453 residues
All mutations
280
PTM sites
40
CDS
36,164,431 - 36,259,409
Transcription
36,160,097 - 36,260,987
35.54% of sequence is predicted to be disordered

Usage summary

Network

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PTM site

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Kinases group

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Kinase, PTM site or protein

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External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 861
UniProt
Ensembl