ATR (NM_001184) - ATR serine/threonine kinase
Serine/threonine-Protein Kinase Atr Isoform 1
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Protein
Kinases
Sites
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Protein summary
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017].
- Strand
- -
- Chromosome
- 3
- Protein
- 2644 residues
- All mutations
- 397
- PTM sites
- 73
- CDS
- 142,168,270 - 142,297,546
- Transcription
- 142,168,076 - 142,297,668
Usage summary
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PTM site
Kinases group
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Kinase, PTM site or protein
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