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PRKAG1 (NM_002733) - protein kinase AMP-activated non-catalytic subunit gamma 1

5'-Amp-Activated Protein Kinase Subunit Gamma-1 Isoform 1

PTM Interaction Network Visualisation

Protein summary

This is preferred isoform of PRKAG1 protein. View all 3 isoforms
PRKAG1: 5'-AMP-activated protein kinase subunit gamma-1 isoform 1
Description:

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].

Strand
-
Chromosome
12
Protein
331 residues
All mutations
35
PTM sites
12
CDS
49,396,681 - 49,412,523
Transcription
49,396,054 - 49,412,629
7.85% of sequence is predicted to be disordered

Usage summary

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External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 5571
UniProt
Ensembl