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TAF2 (NM_003184) - TATA-box binding protein associated factor 2

Transcription Initiation Factor Tfiid Subunit 2

PTM Interaction Network Visualisation
The PTM Interaction Network provides visualization of all PTMs which mediate an interaction between your protein of interest and protein kinases. Each PTM is visualized as a different colour box listing the mutation location and the surrounding amino acid sequence. These PTMs originate from your protein of interest (circle with a dark border) which links it to a kinase (circle with thick border). The colour of the circles corresponds to the number of mutations occurring in the kinase with white being none, and dark blue being a normalized maximum. See figure legend for additional details.

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Protein summary
The protein summary provides brief information regarding your protein, namely: its full name, a brief description of its function, and genomic location of the coding gene.

This is preferred isoform of TAF2 protein.
TAF2: transcription initiation factor TFIID subunit 2
Description:

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008].

Publication Note:
This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

Evidence data:
Transcript exon combination :: SRR1803612.244309.1, SRR1803617.209544.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350]

##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000378164.7/ ENSP00000367406.2 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##

Strand
-
Chromosome
8
Protein
1199 residues
All mutations
144
PTM sites
29
CDS
120,744,163 - 120,844,804
Transcription
120,743,013 - 120,845,074
21.1% of sequence is predicted to be disordered

Usage summary

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External references
RefSeq, Entrez, Uniprot and Enzembl IDs related to your search query.

Mappings retrieved from NCBI & UniProt.
RefSeq
RefSeq IDs relevant to your search query.
Entrez
gene: 6873
UniProt
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Ensembl