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PRMT5 (NM_006109) - protein arginine methyltransferase 5

Protein Arginine N-Methyltransferase 5 Isoform A

PTM Interaction Network Visualisation

Protein summary

This is preferred isoform of PRMT5 protein. View all 6 isoforms
PRMT5: protein arginine N-methyltransferase 5 isoform a
Description:

This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].

Strand
-
Chromosome
14
Protein
637 residues
All mutations
67
PTM sites
26
CDS
23,390,112 - 23,398,570
Transcription
23,389,719 - 23,398,794
4.4% of sequence is predicted to be disordered

Usage summary

Network

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PTM site

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Kinases group

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Kinase, PTM site or protein

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External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 10419
UniProt
Ensembl