DCN (NM_133504) - decorin
Decorin Isoform B Precursor
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Protein
Kinases
Sites
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PTM Interaction Network Visualisation
Protein summary
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015].
- Strand
- -
- Chromosome
- 12
- Protein
- 250 residues
- All mutations
- 56
- PTM sites
- 5
- CDS
- 91,539,834 - 91,572,329
- Transcription
- 91,537,053 - 91,572,423
Usage summary
Network
PTM site
Kinases group
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Kinase, PTM site or protein
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