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DCN (NM_133504) - decorin

Decorin Isoform B Precursor

PTM Interaction Network Visualisation

Protein summary

This is an alternative isoform of DCN protein. View all 6 isoforms
DCN: decorin isoform b precursor
Description:

This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015].

Strand
-
Chromosome
12
Protein
250 residues
All mutations
56
PTM sites
5
CDS
91,539,834 - 91,572,329
Transcription
91,537,053 - 91,572,423
10.8% of sequence is predicted to be disordered

Usage summary

Network

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PTM site

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Kinases group

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Kinase, PTM site or protein

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External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 1634
UniProt
Ensembl