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STAT3 (NM_213662) - signal transducer and activator of transcription 3

Signal Transducer And Activator Of Transcription 3 Isoform 3

PTM Interaction Network Visualisation
The PTM Interaction Network provides visualization of all PTMs which mediate an interaction between your protein of interest and protein kinases. Each PTM is visualized as a different colour box listing the mutation location and the surrounding amino acid sequence. These PTMs originate from your protein of interest (circle with a dark border) which links it to a kinase (circle with thick border). The colour of the circles corresponds to the number of mutations occurring in the kinase with white being none, and dark blue being a normalized maximum. See figure legend for additional details.

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If there is a specific PTM you are interested in, you can click on it to zoom onto it and the kinases it has been associated with. Alternatively you can click the magnifying glass icons on the top right of the PTM Interaction Network Visualisation window.

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Protein summary
The protein summary provides brief information regarding your protein, namely: its full name, a brief description of its function, and genomic location of the coding gene.

This is an alternative isoform of STAT3 protein. View all 3 isoforms
STAT3: signal transducer and activator of transcription 3 isoform 3
Description:

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020].

Strand
-
Chromosome
17
Protein
722 residues
All mutations
161
PTM sites
48
CDS
40,468,844 - 40,500,534
Transcription
40,465,342 - 40,540,405
9.56% of sequence is predicted to be disordered

Usage summary

Network

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External references
RefSeq, Entrez, Uniprot and Enzembl IDs related to your search query.

Mappings retrieved from NCBI & UniProt.
RefSeq
RefSeq IDs relevant to your search query.
Entrez
gene: 6774
UniProt
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Ensembl