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TP53 (NM_001126116) - tumor protein p53

Cellular Tumor Antigen P53 Isoform E

PTM Interaction Network Visualisation

Protein summary

This is an alternative isoform of TP53 protein. View all 15 isoforms
TP53: cellular tumor antigen p53 isoform e
Description:

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016].

Strand
-
Chromosome
17
Protein
209 residues
All mutations
587
PTM sites
25
CDS
7,576,624 - 7,578,533
Transcription
7,571,719 - 7,578,811
16.27% of sequence is predicted to be disordered

Usage summary

Network

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PTM site

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Kinases group

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Kinase, PTM site or protein

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External references

Mappings retrieved from NCBI & UniProt.
RefSeq
Entrez
gene: 7157
UniProt
Ensembl